R 8231

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585093

CAS#: 50648-52-7

Description: R 8231 inhibits ATP-ase.


Chemical Structure

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R 8231
CAS# 50648-52-7

Theoretical Analysis

MedKoo Cat#: 585093
Name: R 8231
CAS#: 50648-52-7
Chemical Formula: C13H11BrN2O4S
Exact Mass: 369.96
Molecular Weight: 371.205
Elemental Analysis: C, 42.06; H, 2.99; Br, 21.53; N, 7.55; O, 17.24; S, 8.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: R 8231; R8231; R-8231

IUPAC/Chemical Name: Imidazo(2,1-b)thiazole, 6-(3-bromophenyl)-5,6-dihydro-, (+-)-, ethanedioate (1:1)

InChi Key: RLCKOBLWSSOAOS-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H9BrN2S.C2H2O4/c12-9-3-1-2-8(6-9)10-7-14-4-5-15-11(14)13-10;3-1(4)2(5)6/h1-6,10H,7H2;(H,3,4)(H,5,6)

SMILES Code: BrC1=CC(C2N=C3SC=CN3C2)=CC=C1.O=C(O)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 371.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Simmons DJ, Arsenis C, Whitson SW, Kahn SE, Boskey AL, Gollub N. Mineralization of rat epiphyseal cartilage: a circadian rhythm. Miner Electrolyte Metab. 1983 Jan-Feb;9(1):28-37. PubMed PMID: 6221186.

2: Engström C, Granström G. Alkaline phosphatases in endochondral ossification of rats low in calcium and vitamin D deficient. Acta Orthop Scand. 1982 Jun;53(3):317-23. PubMed PMID: 7090756.

3: Granström G, Jontell M, Linde A. Separation of odontoblast Ca2+-ATPase and alkaline phosphatase. Calcif Tissue Int. 1979 Jul 3;27(3):211-7. PubMed PMID: 158425.

4: Granström G, Linde A, Nygren H. Ultrastructural localization of alkaline phosphatases in rat incisor odontoblasts. J Histochem Cytochem. 1978 May;26(5):359-68. PubMed PMID: 26717.

5: Mörnstad H. Calcium-stimulated ATPase activity in homogenates of the secretory enamel organ in the rat. Scand J Dent Res. 1978 Jan;86(1):1-11. PubMed PMID: 24889.

6: Granström G, Linde A. A comparison of ATP-degrading enzyme activities in rat incisor odontoblasts. J Histochem Cytochem. 1976 Sep;24(9):1026-32. PubMed PMID: 9454.

7: Van Belle H. Alkaline phosphatase. I. Kinetics and inhibition by levamisole of purified isoenzymes from humans. Clin Chem. 1976 Jul;22(7):972-6. PubMed PMID: 6169.

8: Larsson A. Histochemical localization of alkaline pyrophosphate- phosphohydrolase in tooth-forming cells of rat. Scand J Dent Res. 1976 Mar;84(2):63-75. PubMed PMID: 176719.

9: Linde A, Magnusson BC. Inhibition studies of alkaline phosphatase in hard tissue-forming cells. J Histochem Cytochem. 1975 May;23(5):342-7. PubMed PMID: 165233.

10: Fredén H, Linde A, Magnusson BC. Inorganic pyrophosphatase in isolated enamel organ and odontoblasts from the rat incisor. Acta Odontol Scand. 1975;33(3):143-8. PubMed PMID: 9771.