WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573870

CAS#: 14949-00-9

Description: Zolamide may be used to prevent and reduce the symptoms of altitude sickness.

Chemical Structure

CAS# 14949-00-9

Theoretical Analysis

MedKoo Cat#: 573870
Name: Zolamide
CAS#: 14949-00-9
Chemical Formula: C2H4N4O2S2
Exact Mass: 179.98
Molecular Weight: 180.200
Elemental Analysis: C, 13.33; H, 2.24; N, 31.09; O, 17.76; S, 35.58

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100mg USD 450
250mg USD 750
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Related CAS #: 72296-05-0 (sodium)  

Synonym: 5-Amino-TDSNH2, CL 5343, Tio-urasin, Zolamide

IUPAC/Chemical Name: 1,3,4-Thiadiazole-2-sulfonamide, 5-amino- (8CI)(9CI)


InChi Code: 1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)

SMILES Code: c1(nnc(s1)S(=O)(=O)N)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 180.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Van Berkel MA, Elefritz JL. Evaluating off-label uses of acetazolamide. Am J Health Syst Pharm. 2018 Apr 15;75(8):524-531. doi: 10.2146/ajhp170279. Review. PubMed PMID: 29626002.

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3: Llovet-Rausell A, Ruiz Tolosa F, Kudsieh B. Severe ocular side effects with acetazolamide: case report. Arch Soc Esp Oftalmol. 2016 Nov;91(11):543-546. doi: 10.1016/j.oftal.2016.03.013. Epub 2016 May 11. English, Spanish. PubMed PMID: 27179669.

4: Al-Saleem AI, Al-Jobair AM. Possible association between acetazolamide administration during pregnancy and multiple congenital malformations. Drug Des Devel Ther. 2016 Apr 15;10:1471-6. doi: 10.2147/DDDT.S99561. eCollection 2016. PubMed PMID: 27143854; PubMed Central PMCID: PMC4841426.

5: Santoveña A, Suárez-González J, Martín-Rodríguez C, Fariña JB. Formulation design of oral pediatric Acetazolamide suspension: dose uniformity and physico-chemical stability study. Pharm Dev Technol. 2017 Mar;22(2):191-197. doi: 10.1080/10837450.2016.1175475. Epub 2016 Apr 24. PubMed PMID: 27109383.

6: Biondich AS, Joslin JD. Acetazolamide Use in an Ultra-Runner: A Complicated Treatment Consideration for AMS. Wilderness Environ Med. 2016 Mar;27(1):179-80. doi: 10.1016/j.wem.2015.09.001. Epub 2015 Oct 29. PubMed PMID: 26520404.

7: Supuran CT. Acetazolamide for the treatment of idiopathic intracranial hypertension. Expert Rev Neurother. 2015;15(8):851-6. doi: 10.1586/14737175.2015.1066675. Epub 2015 Jul 7. Review. PubMed PMID: 26154918.

8: Falardeau J, Lobb BM, Golden S, Maxfield SD, Tanne E. The use of acetazolamide during pregnancy in intracranial hypertension patients. J Neuroophthalmol. 2013 Mar;33(1):9-12. doi: 10.1097/WNO.0b013e3182594001. PubMed PMID: 22635167.

9: Kassamali R, Sica DA. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8. doi: 10.1097/CRD.0b013e31822b4939. Review. PubMed PMID: 21983315.

10: Reiss WG, Oles KS. Acetazolamide in the treatment of seizures. Ann Pharmacother. 1996 May;30(5):514-9. Review. PubMed PMID: 8740334.