N-Methyl amisulpride
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MedKoo CAT#: 573858

CAS#: 1391054-22-0

Description: N-Methyl amisulpride is an impurity of Amisulpride.


Chemical Structure

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N-Methyl amisulpride
CAS# 1391054-22-0

Theoretical Analysis

MedKoo Cat#: 573858
Name: N-Methyl amisulpride
CAS#: 1391054-22-0
Chemical Formula: C18H29N3O4S
Exact Mass: 383.19
Molecular Weight: 383.510
Elemental Analysis: C, 56.37; H, 7.62; N, 10.96; O, 16.69; S, 8.36

Price and Availability

Size Price Availability Quantity
10mg USD 355
50mg USD 1085
100mg USD 1850
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Synonym: Amisulpride impurity H, Amisulpride EP impurity H, N-Methyl amisulpride, N-Methylamisulpride

IUPAC/Chemical Name: Benzamide, 4-amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-N-methyl-

InChi Key: PMLIJXXZFCRLES-UHFFFAOYSA-N

InChi Code: 1S/C18H29N3O4S/c1-5-21-9-7-8-13(21)12-20(3)18(22)14-10-17(26(23,24)6-2)15(19)11-16(14)25-4/h10-11,13H,5-9,12,19H2,1-4H3

SMILES Code: CCN1CCCC1CN(C)C(=O)c2cc(c(N)cc2OC)S(=O)(=O)CC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 383.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Barnes TR, Leeson VC, Paton C, Marston L, Davies L, Whittaker W, Osborn D, Kumar R, Keown P, Zafar R, Iqbal K, Singh V, Fridrich P, Fitzgerald Z, Bagalkote H, Haddad PM, Husni M, Amos T. Amisulpride augmentation in clozapine-unresponsive schizophrenia (AMICUS): a double-blind, placebo-controlled, randomised trial of clinical effectiveness and cost-effectiveness. Health Technol Assess. 2017 Sep;21(49):1-56. doi: 10.3310/hta21490. PubMed PMID: 28869006; PubMed Central PMCID: PMC5601255.

2: Herrstedt J, Summers Y, Daugaard G, Christensen TB, Holmskov K, Taylor PD, Fox GM, Molassiotis A. Amisulpride in the prevention of nausea and vomiting induced by cisplatin-based chemotherapy: a dose-escalation study. Support Care Cancer. 2018 Jan;26(1):139-145. doi: 10.1007/s00520-017-3825-2. Epub 2017 Aug 11. PubMed PMID: 28801850.

3: Gan TJ, Kranke P, Minkowitz HS, Bergese SD, Motsch J, Eberhart L, Leiman DG, Melson TI, Chassard D, Kovac AL, Candiotti KA, Fox G, Diemunsch P. Intravenous Amisulpride for the Prevention of Postoperative Nausea and Vomiting: Two Concurrent, Randomized, Double-blind, Placebo-controlled Trials. Anesthesiology. 2017 Feb;126(2):268-275. doi: 10.1097/ALN.0000000000001458. PubMed PMID: 27902493.

4: Arora M, Banal R, Praharaj SK, Mahajan V. Amisulpride Augmentation in Acute Catatonia. Am J Ther. 2017 Jul/Aug;24(4):e381-e385. doi: 10.1097/MJT.0000000000000311. PubMed PMID: 26270797.