8-CPT-AM

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558715

CAS#: 1152197-23-3

Description: 8-CPT-AM is a selective activator of Epac.

Chemical Structure

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8-CPT-AM
CAS# 1152197-23-3
Instruction

Theoretical Analysis

MedKoo Cat#: 558715
Name: 8-CPT-AM
CAS#: 1152197-23-3
Chemical Formula: C20H21ClN5O8PS
Exact Mass: 557.05
Molecular Weight: 557.900
Elemental Analysis: C, 43.06; H, 3.79; Cl, 6.35; N, 12.55; O, 22.94; P, 5.55; S, 5.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 007AM; 007 AM; 007-AM; 8 CPT-AM; 8-CPT AM; 8-CPT-AM

IUPAC/Chemical Name: (((4aR,6R,7R,7aR)-6-(6-amino-8-((4-chlorophenyl)thio)-9H-purin-9-yl)-7-methoxy-2-oxidotetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-yl)oxy)methyl acetate

InChi Key: FZMWUFYPEVDWPA-SILPBKOMSA-N

InChi Code: InChI=1S/C20H21ClN5O8PS/c1-10(27)30-9-32-35(28)31-7-13-15(34-35)16(29-2)19(33-13)26-18-14(17(22)23-8-24-18)25-20(26)36-12-5-3-11(21)4-6-12/h3-6,8,13,15-16,19H,7,9H2,1-2H3,(H2,22,23,24)/t13-,15-,16-,19-,35?/m1/s1

SMILES Code: NC1=C2C(N([C@@H]3O[C@H](COP(O4)(OCOC(C)=O)=O)[C@@H]4[C@H]3OC)C(SC5=CC=C(Cl)C=C5)=N2)=NC=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 557.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Laudette M, Coluccia A, Sainte-Marie Y, Solari A, Fazal L, Sicard P, Silvestri R, Mialet-Perez J, Pons S, Ghaleh B, Blondeau JP, Lezoualc'h F. Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress. Cardiovasc Res. 2019 Mar 14. pii: cvz076. doi: 10.1093/cvr/cvz076. [Epub ahead of print] PubMed PMID: 30873562.

2: Liu Y, Schneider MF. Opposing HDAC4 nuclear fluxes due to phosphorylation by β-adrenergic activated protein kinase A or by activity or Epac activated CaMKII in skeletal muscle fibres. J Physiol. 2013 Jul 15;591(14):3605-23. doi: 10.1113/jphysiol.2013.256263. Epub 2013 May 7. PubMed PMID: 23652597; PubMed Central PMCID: PMC3731617.

3: Brette F, Blandin E, Simard C, Guinamard R, Sallé L. Epac activator critically regulates action potential duration by decreasing potassium current in rat adult ventricle. J Mol Cell Cardiol. 2013 Apr;57:96-105. doi: 10.1016/j.yjmcc.2013.01.012. Epub 2013 Jan 30. PubMed PMID: 23376036.

4: Chang CW, Chang GD, Chen H. A novel cyclic AMP/Epac1/CaMKI signaling cascade promotes GCM1 desumoylation and placental cell fusion. Mol Cell Biol. 2011 Sep;31(18):3820-31. doi: 10.1128/MCB.05582-11. Epub 2011 Jul 26. PubMed PMID: 21791615; PubMed Central PMCID: PMC3165715.