RB 104

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585083

CAS#: 145253-48-1

Description: RB 104 is a potent inhibitor of EC 3.4.24.11 that is used to detect nanogram quantities of the enzyme by inhibitor gel electrophoresis.

Chemical Structure

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RB 104
CAS# 145253-48-1
Instruction

Theoretical Analysis

MedKoo Cat#: 585083
Name: RB 104
CAS#: 145253-48-1
Chemical Formula: C21H23IN2O6
Exact Mass: 526.06
Molecular Weight: 526.328
Elemental Analysis: C, 47.92; H, 4.40; I, 24.11; N, 5.32; O, 18.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RB 104; RB104; RB-104

IUPAC/Chemical Name: Benzenepropanoic acid, 4-hydroxy-alpha-(2-((3-(hydroxyamino)-3-oxo-1-(phenylmethyl)propyl)amino)-2-oxoethyl)-3-iodo-

InChi Key: SPYDLFCJSOZVCF-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H23IN2O6/c22-17-10-14(6-7-18(17)25)8-15(21(28)29)11-19(26)23-16(12-20(27)24-30)9-13-4-2-1-3-5-13/h1-7,10,15-16,25,30H,8-9,11-12H2,(H,23,26)(H,24,27)(H,28,29)

SMILES Code: O=C(O)C(CC(NC(CC1=CC=CC=C1)CC(NO)=O)=O)CC2=CC=C(O)C(I)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 526.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hubner RA, Kubota E, Casley DJ, Johnston CI, Burrell LM. In-vitro and in-vivo inhibition of rat neutral endopeptidase and angiotensin converting enzyme with the vasopeptidase inhibitor gemopatrilat. J Hypertens. 2001 May;19(5):941-6. PubMed PMID: 11393678.

2: Zappulla JP, Wickham L, Bawab W, Yang XF, Storozhuk MV, Castellucci VF, DesGroseillers L. Cloning and characterization of Aplysia neutral endopeptidase, a metallo-endopeptidase involved in the extracellular metabolism of neuropeptides in Aplysia californica. J Neurosci. 1999 Jun 1;19(11):4280-92. PubMed PMID: 10341232.

3: Burrell LM, Farina N, Risvanis J, Woollard D, Casely D, Johnston CI. Inhibition of neutral endopeptidase, the degradative enzyme for natriuretic peptides, in rat kidney after oral SCH 42495. Clin Sci (Lond). 1997 Jul;93(1):43-50. PubMed PMID: 9279202.

4: Tharaux PL, Stefanski A, Ledoux S, Soleilhac JM, Ardaillou R, Dussaule JC. EGF and TGF-beta regulate neutral endopeptidase expression in renal vascular smooth muscle cells. Am J Physiol. 1997 Jun;272(6 Pt 1):C1836-43. PubMed PMID: 9227412.

5: Bawab W, Aloyz RS, Crine P, Roques BP, DesGroseillers L. Identification and characterization of a neutral endopeptidase activity in Aplysia californica. Biochem J. 1993 Dec 1;296 ( Pt 2):459-65. PubMed PMID: 8257438; PubMed Central PMCID: PMC1137717.

6: Landry C, Santagata P, Bawab W, Fournié-Zaluski MC, Roques BP, Vinay P, Crine P. Characterization of neutral endopeptidase 24.11 in dog glomeruli. Biochem J. 1993 May 1;291 ( Pt 3):773-9. PubMed PMID: 8489505; PubMed Central PMCID: PMC1132435.

7: Fournié-Zaluski MC, Soleilhac JM, Turcaud S, Laï-Kuen R, Crine P, Beaumont A, Roques BP. Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis". Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6388-92. PubMed PMID: 1385873; PubMed Central PMCID: PMC49506.