Amifostine sodium

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MedKoo CAT#: 573844

CAS#: 59178-37-9 (sodium)

Description: Amifostine sodium is a phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.


Chemical Structure

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Amifostine sodium
CAS# 59178-37-9 (sodium)

Theoretical Analysis

MedKoo Cat#: 573844
Name: Amifostine sodium
CAS#: 59178-37-9 (sodium)
Chemical Formula: C5H13N2Na2O3PS
Exact Mass: 258.02
Molecular Weight: 258.180
Elemental Analysis: C, 23.26; H, 5.08; N, 10.85; Na, 17.81; O, 18.59; P, 12.00; S, 12.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 20537-88-6 (free)   112901-68-5 (trihydrate)   59178-37-9 (sodium)   63717-27-1 (monohydrate)  

Synonym: Amifostine sodium, WR 2721 sodium, WR2721 sodium, WR-2721 sodium

IUPAC/Chemical Name: Phosphorothioic acid, S-(2-((3-aminopropyl)amino)ethyl) ester, disodium salt

InChi Key: SWWAWQGXMDVHTK-UHFFFAOYSA-L

InChi Code: 1S/C5H15N2O3PS.2Na/c6-2-1-3-7-4-5-12-11(8,9)10;;/h7H,1-6H2,(H2,8,9,10);;/q;2*+1/p-2

SMILES Code: [Na+].[Na+].NCCCNCCSP(=O)([O-])[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 258.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jaćević V, Dragojević-Simić V, Tatomirović Ž, Dobrić S, Bokonjić D, Kovačević
A, Nepovimova E, Vališ M, Kuča K. The Efficacy of Amifostine against
Multiple-Dose Doxorubicin-Induced Toxicity in Rats. Int J Mol Sci. 2018 Aug
12;19(8). pii: E2370. doi: 10.3390/ijms19082370. PubMed PMID: 30103540.

2: Sueishi Y, Nii R. Monoterpene's multiple free radical scavenging capacity as
compared with the radioprotective agent cysteamine and amifostine. Bioorg Med
Chem Lett. 2018 Aug 2. pii: S0960-894X(18)30652-8. doi:
10.1016/j.bmcl.2018.08.003. [Epub ahead of print] PubMed PMID: 30098868.