Amlodipine hydrochloride

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MedKoo CAT#: 573792

CAS#: 246852-07-3 (HCl)

Description: Amlodipine hydrochloride is a salt of Amlodipine --- a medication used to lower blood pressure and prevent chest pain.


Chemical Structure

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Amlodipine hydrochloride
CAS# 246852-07-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 573792
Name: Amlodipine hydrochloride
CAS#: 246852-07-3 (HCl)
Chemical Formula: C20H26Cl2N2O5
Exact Mass: 444.12
Molecular Weight: 445.340
Elemental Analysis: C, 53.94; H, 5.88; Cl, 15.92; N, 6.29; O, 17.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 88150-42-9 (free base)   88150-47-4 (maleate)   111470-99-6 (besylate)   246852-07-3 (HCl)   246852-09-5 (HBr)   246852-12-0 (mesylate)   440358-84-9 (mesylate hydrate)    

Synonym: Amlodipine hydrochloride, Amlodipine HCl

IUPAC/Chemical Name: 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, hydrochloride (1:1)

InChi Key: BSBOZVBRVBLCLO-UHFFFAOYSA-N

InChi Code: 1S/C20H25ClN2O5.ClH/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;/h5-8,17,23H,4,9-11,22H2,1-3H3;1H

SMILES Code: Cl.CCOC(=O)C1=C(COCCN)NC(=C(C1c2ccccc2Cl)C(=O)OC)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gottwald-Hostalek U, Sun N, Barho C, Hildemann S. Management of Hypertension With a Fixed-Dose (Single-Pill) Combination of Bisoprolol and Amlodipine. Clin Pharmacol Drug Dev. 2017 Jan;6(1):9-18. doi: 10.1002/cpdd.309. Epub 2016 Oct 26. PubMed PMID: 27653022.

2: van Zwieten PA. Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. Review. PubMed PMID: 9156957.