Amlodipine maleate | CAS# 88150-47-4 | calcium channel blocker

Amlodipine maleate
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573789

CAS#: 88150-47-4 (maleate)

Description: Amlodipine maleate is a long-acting dihydropyridine calcium channel blocker effective in the treatment of angina pectoris and hypertension.

Chemical Structure

Amlodipine maleate

CAS# 88150-47-4 (maleate)

Instruction

Theoretical Analysis

MedKoo Cat#: 573789
Name: Amlodipine maleate
CAS#: 88150-47-4 (maleate)
Chemical Formula: C24H29ClN2O9
Exact Mass: 524.16
Molecular Weight: 524.950
Elemental Analysis: C, 54.91; H, 5.57; Cl, 6.75; N, 5.34; O, 27.43

Price and Availability

Size	Price	Availability
50mg	USD 250	2 Weeks
100mg	USD 450	2 Weeks
500mg	USD 850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 88150-42-9 (free base) 88150-47-4 (maleate) 111470-99-6 (besylate) 246852-07-3 (HCl) 246852-09-5 (HBr) 246852-12-0 (mesylate) 440358-84-9 (mesylate hydrate)

Synonym: Amlodipine (+-)-form maleate, Amlodipine maleate, Amvaz

IUPAC/Chemical Name: 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, (Z)-2-butenedioate (1:1)

InChi Key: TZNOWAJJWCGILX-BTJKTKAUSA-N

InChi Code: 1S/C20H25ClN2O5.C4H4O4/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;5-3(6)1-2-4(7)8/h5-8,17,23H,4,9-11,22H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

SMILES Code: C=1([C@@H](C(=C(NC1COCCN)C)C(OC)=O)c1c(cccc1)Cl)C(OCC)=O.OC(\C=C/C(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 524.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: van Zwieten PA. Amlodipine: an overview of its pharmacodynamic and pharmacokinetic properties. Clin Cardiol. 1994 Sep;17(9 Suppl 3):III3-6. PMID: 9156957.

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16: Drobotya NV, Torosyan SS, Guseynova ES, Morgunov MN. Effect of Perindopril / Amlodipine Fixed Combination on Ultrasound Characteristics of Ventricles of the Heart in Patients with Ischemic Heart Disease and Arterial Hypertension. Kardiologiia. 2019 Jan 27;59(1):22-27. Russian. doi: 10.18087/cardio.2019.1.10212. PMID: 30710985.

17: Mignini F, Tomassoni D, Traini E, Amenta F. Single-dose, randomized, crossover bioequivalence study of amlodipine maleate versus amlodipine besylate in healthy volunteers. Clin Exp Hypertens. 2007 Nov;29(8):539-52. doi: 10.1080/10641960701744046. PMID: 18058479.

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