UDM-001651

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MedKoo CAT#: 555591

CAS#: 1477497-01-0

Description: UDM-001651 is a potent , selective and orally active Protease-Activated Receptor 4 (PAR4) Antagonist with in Vivo Antithrombotic Efficacy (IC50 = 2.4 nM). UDM-001651 was evaluated in a monkey thrombosis model and shown to have robust antithrombotic efficacy and no prolongation of kidney bleeding time. This combination of excellent efficacy and safety margin strongly validates PAR4 antagonism as a promising antithrombotic mechanism.


Price and Availability

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Pricing updated 2020-10-29. Prices are subject to change without notice.

UDM-001651 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555591
Name: UDM-001651
CAS#: 1477497-01-0
Chemical Formula: C28H23N3O5S
Exact Mass: 513.1358
Molecular Weight: 513.568
Elemental Analysis: C, 65.48; H, 4.51; N, 8.18; O, 15.58; S, 6.24


Synonym: UDM-001651; UDM 001651; UDM001651; UDM-1651; UDM 1651; UDM1651;

IUPAC/Chemical Name: 6-(4-((3-(Benzyloxy)benzyl)oxy)-6-methoxybenzofuran-2-yl)-2-methoxyimidazo[2,1-b][1,3,4]thiadiazole

InChi Key: LFOIDLOIBZFWDO-UHFFFAOYSA-N

InChi Code: InChI=1S/C28H23N3O5S/c1-32-21-12-24(35-17-19-9-6-10-20(11-19)34-16-18-7-4-3-5-8-18)22-14-26(36-25(22)13-21)23-15-31-27(29-23)37-28(30-31)33-2/h3-15H,16-17H2,1-2H3

SMILES Code: COC1=NN2C(S1)=NC(C3=CC4=C(OCC5=CC=CC(OCC6=CC=CC=C6)=C5)C=C(OC)C=C4O3)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

Atherothrombotic cardiovascular and cerebrovascular diseases are the leading cause of morbidity and mortality in developed countries and claim more lives each year than cancer in the United States.1 Atherothrombotic diseases, such as acute coronary syndrome and stroke, originate with a gradual buildup of plaque in the arterial wall. The eventual rupture of an atherosclerotic plaque exposes a prothrombotic milieu to the blood and activates platelets at the site of the injury, leading to the formation of a potentially occlusive thrombus and subsequent ischemia.


References

1: Miller MM, Banville J, Friends TJ, Gagnon M, Hangeland JJ, Lavallée JF, Martel
A, O'Grady H, Rémillard R, Ruediger E, Tremblay F, Posy SL, Allegretto NJ,
Guarino VR, Harden DG, Harper TW, Hartl K, Josephs J, Malmstrom S, Watson C, Yang
Y, Zhang G, Wong P, Yang J, Bouvier M, Seiffert DA, Wexler RR, Lawrence RM,
Priestley ES, Marinier A. Discovery of Potent Protease-Activated Receptor 4
Antagonists with in Vivo Antithrombotic Efficacy. J Med Chem. 2019 Aug 5. doi:
10.1021/acs.jmedchem.9b00186. [Epub ahead of print] PubMed PMID: 31246024.