AMD-3451 trihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573782

CAS#: 255382-96-8

Description: AMD-3451 trihydrochloride is a CCR5/CXCR4 dual antagonist that may be useful in the treatment of HIV.


Chemical Structure

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AMD-3451 trihydrochloride
CAS# 255382-96-8

Theoretical Analysis

MedKoo Cat#: 573782
Name: AMD-3451 trihydrochloride
CAS#: 255382-96-8
Chemical Formula: C16H30Cl5N5
Exact Mass: 467.09
Molecular Weight: 469.700
Elemental Analysis: C, 40.91; H, 6.44; Cl, 37.74; N, 14.91

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AMD-3451 trihydrochloride, AMD 3451 trihydrochloride, AMD3451 trihydrochloride

IUPAC/Chemical Name: 1,4,8,11-Tetraazacyclotetradecane, 1-((2,6-dichloro-4-pyridinyl)methyl)-, trihydrochloride

InChi Key: VMPSPJAKJZDOSU-UHFFFAOYSA-N

InChi Code: 1S/C16H27Cl2N5.3ClH/c17-15-11-14(12-16(18)22-15)13-23-9-2-5-20-7-6-19-3-1-4-21-8-10-23;;;/h11-12,19-21H,1-10,13H2;3*1H

SMILES Code: c1c(cc(nc1Cl)Cl)CN2CCCNCCNCCCNCC2.Cl.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 469.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Grande F, Occhiuzzi MA, Rizzuti B, Ioele G, De Luca M, Tucci P, Svicher V, Aquaro S, Garofalo A. CCR5/CXCR4 Dual Antagonism for the Improvement of HIV Infection Therapy. Molecules. 2019 Feb 2;24(3). pii: E550. doi: 10.3390/molecules24030550. Review. PubMed PMID: 30717348; PubMed Central PMCID: PMC6384722.

2: Princen K, Hatse S, Vermeire K, Aquaro S, De Clercq E, Gerlach LO, Rosenkilde M, Schwartz TW, Skerlj R, Bridger G, Schols D. Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist. J Virol. 2004 Dec;78(23):12996-3006. PubMed PMID: 15542651; PubMed Central PMCID: PMC524989.