Mafenide acetate
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MedKoo CAT#: 573776

CAS#: 138-39-6 (acetate)

Description: Mafenide acetate is a sulfonamide that inhibits the enzyme carbonic anhydrase and is used as topical anti-infective, especially in burn therapy.


Chemical Structure

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Mafenide acetate
CAS# 138-39-6 (acetate)

Theoretical Analysis

MedKoo Cat#: 573776
Name: Mafenide acetate
CAS#: 138-39-6 (acetate)
Chemical Formula: C7H10N2O2S
Exact Mass: 186.0463
Molecular Weight: 186.23
Elemental Analysis: C, 45.15; H, 5.41; N, 15.04; O, 17.18; S, 17.22

Price and Availability

Size Price Availability Quantity
100.0mg USD 225.0 2 Weeks
250.0mg USD 350.0 2 Weeks
500.0mg USD 535.0 2 Weeks
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Related CAS #: 138-39-6 (free base)   12001-72-8 (propionate)   138-37-4 (HCl)   138-39-6 (acetate)  

Synonym: Ambamide, Benzamsulfonamide, Emilene, Homonal, Homosul, Mafenide, Marprontil, Mesudin, Mesudrin, Septicid

IUPAC/Chemical Name: Benzenesulfonamide, 4-(aminomethyl)-

InChi Key: TYMRLRRVMHJFTF-UHFFFAOYSA-N

InChi Code: 1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)

SMILES Code: c1cc(ccc1CN)S(=O)(=O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 186.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kahn SA, Afshari A, Nguyen L, Shinha T, Huff T, Montgomery AC, Stratton C, Summitt B. Hydrofiber Dressing Saturated With Mafenide Acetate Extends the Duration of Antimicrobial Activity. J Burn Care Res. 2017 Jul/Aug;38(4):e704-e707. doi: 10.1097/BCR.0000000000000455. PubMed PMID: 27775984.

2: Afshari A, Nguyen L, Kahn SA, Summitt B. 2.5% Mafenide Acetate: A Cost-Effective Alternative to the 5% Solution for Burn Wounds. J Burn Care Res. 2017 Jan/Feb;38(1):e42-e47. doi: 10.1097/BCR.0000000000000425. PubMed PMID: 27606553.

3: Pickus EJ, Lionelli GT, Charles EW 3rd, Korentager RA. Mafenide acetate allergy presenting as recurrent chondritis. Ann Plast Surg. 2002 Feb;48(2):202-4. PubMed PMID: 11910229.