WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573767

CAS#: 414858-51-8

Description: AM-112 is an Oxapenem compound which possesses potent beta-lactamase-inhibitory properties.

Chemical Structure

CAS# 414858-51-8

Theoretical Analysis

MedKoo Cat#: 573767
Name: AM-112
CAS#: 414858-51-8
Chemical Formula: C14H22N2O5
Exact Mass: 298.1529
Molecular Weight: 298.34
Elemental Analysis: C, 56.36; H, 7.43; N, 9.39; O, 26.81

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AM-112, AM112, AM 112

IUPAC/Chemical Name: 4-Oxa-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(4-amino-1,1-dimethylbutyl)-6-((1R)-1-hydroxyethyl)-7-oxo-, (5R,6R)-


InChi Code: 1S/C14H22N2O5/c1-7(17)8-11(18)16-9(13(19)20)10(21-12(8)16)14(2,3)5-4-6-15/h7-8,12,17H,4-6,15H2,1-3H3,(H,19,20)/t7-,8+,12-/m1/s1

SMILES Code: C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(O2)C(C)(C)CCCN)C(=O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 298.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bowker KE, Noel AR, Walsh TR, Rogers CA, MacGowan AP. Pharmacodynamics of ceftazidime plus the serine beta-lactamase inhibitor AM-112 against Escherichia coli containing TEM-1 and CTX-M-1 beta-lactamases. Antimicrob Agents Chemother. 2004 Nov;48(11):4482-4. PubMed PMID: 15504890; PubMed Central PMCID: PMC525393.

2: Simpson IN, Urch CJ, Hagen G, Albrecht R, Sprinkart B, Pfaendler HR. Synthesis and biological activity of AM-112 and related oxapenem analogues. J Antibiot (Tokyo). 2003 Oct;56(10):838-47. PubMed PMID: 14700277.

3: Jamieson CE, Lambert PA, Simpson IN. In vitro and in vivo activities of AM-112, a novel oxapenem. Antimicrob Agents Chemother. 2003 May;47(5):1652-7. PubMed PMID: 12709336; PubMed Central PMCID: PMC153311.