WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573767
Description: AM-112 is an Oxapenem compound which possesses potent beta-lactamase-inhibitory properties.
MedKoo Cat#: 573767
Chemical Formula: C14H22N2O5
Exact Mass: 298.1529
Molecular Weight: 298.34
Elemental Analysis: C, 56.36; H, 7.43; N, 9.39; O, 26.81
This product is not in stock, which may be available by custom synthesis.
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Synonym: AM-112, AM112, AM 112
IUPAC/Chemical Name: 4-Oxa-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 3-(4-amino-1,1-dimethylbutyl)-6-((1R)-1-hydroxyethyl)-7-oxo-, (5R,6R)-
InChi Key: MJNFEDQKHJZAEX-RGNHYFCHSA-N
InChi Code: 1S/C14H22N2O5/c1-7(17)8-11(18)16-9(13(19)20)10(21-12(8)16)14(2,3)5-4-6-15/h7-8,12,17H,4-6,15H2,1-3H3,(H,19,20)/t7-,8+,12-/m1/s1
SMILES Code: C[C@H]([C@@H]1[C@@H]2N(C1=O)C(=C(O2)C(C)(C)CCCN)C(=O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 298.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Bowker KE, Noel AR, Walsh TR, Rogers CA, MacGowan AP. Pharmacodynamics of ceftazidime plus the serine beta-lactamase inhibitor AM-112 against Escherichia coli containing TEM-1 and CTX-M-1 beta-lactamases. Antimicrob Agents Chemother. 2004 Nov;48(11):4482-4. PubMed PMID: 15504890; PubMed Central PMCID: PMC525393.
2: Simpson IN, Urch CJ, Hagen G, Albrecht R, Sprinkart B, Pfaendler HR. Synthesis and biological activity of AM-112 and related oxapenem analogues. J Antibiot (Tokyo). 2003 Oct;56(10):838-47. PubMed PMID: 14700277.
3: Jamieson CE, Lambert PA, Simpson IN. In vitro and in vivo activities of AM-112, a novel oxapenem. Antimicrob Agents Chemother. 2003 May;47(5):1652-7. PubMed PMID: 12709336; PubMed Central PMCID: PMC153311.