WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565778
Description: M1001 is a novel allosteric agonist of hypoxia-inducible factor-2α subunit (hif-2α), significantly displacing pocket residue y281
MedKoo Cat#: 565778
Chemical Formula: C17H17N3O2S
Exact Mass: 327.1041
Molecular Weight: 327.402
Elemental Analysis: C, 62.37; H, 5.23; N, 12.83; O, 9.77; S, 9.79
This product is not in stock, which may be available by custom synthesis.
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Synonym: M1001; M 1001; M-1001
IUPAC/Chemical Name: 3-((2-(Pyrrolidin-1-yl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide
InChi Key: LONXCUOJVJLTIP-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H17N3O2S/c21-23(22)16-10-4-1-7-13(16)17(19-23)18-14-8-2-3-9-15(14)20-11-5-6-12-20/h1-4,7-10H,5-6,11-12H2,(H,18,19)
SMILES Code: O=S1(N=C(NC2=CC=CC=C2N3CCCC3)C4=CC=CC=C41)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 327.402 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: den Bakker HC, Manuel CS, Fortes ED, Wiedmann M, Nightingale KK. Genome sequencing identifies Listeria fleischmannii subsp. coloradonensis subsp. nov., isolated from a ranch. Int J Syst Evol Microbiol. 2013 Sep;63(Pt 9):3257-68. doi: 10.1099/ijs.0.048587-0. Epub 2013 Mar 22. PubMed PMID: 23524352.
2: Wang SL, Shieh ST, Pai CS. Production, purification and characterization of two proteinaceous hen-egg-white lysozyme inhibitors from Pseudomonas aeruginosa M-1001. Proc Natl Sci Counc Repub China B. 1995 Jul;19(3):166-75. PubMed PMID: 7480363.
3: Hukami K. [An attempt at training color vision defectives with Sanvista (M-1001)]. Nippon Ganka Gakkai Zasshi. 1966 Jun;70(6):589-92. Japanese. PubMed PMID: 5297148.
4: Perloff D, Sokolow M, Cowan R. Clinical relevance of ambulatory blood pressure measurements. Biotelem Patient Monit. 1981;8(1-2):67-80. PubMed PMID: 7295924.
5: Wang SL, Pai CS, Shieh ST. Production of lytic enzyme from Pseudomonas aeruginosa M-1001. Proc Natl Sci Counc Repub China B. 1995 Oct;19(4):216-24. PubMed PMID: 8742619.