WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565778

CAS#: 874590-32-6

Description: M1001 is a novel allosteric agonist of hypoxia-inducible factor-2α subunit (hif-2α), significantly displacing pocket residue y281

Chemical Structure

CAS# 874590-32-6

Theoretical Analysis

MedKoo Cat#: 565778
Name: M1001
CAS#: 874590-32-6
Chemical Formula: C17H17N3O2S
Exact Mass: 327.1041
Molecular Weight: 327.402
Elemental Analysis: C, 62.37; H, 5.23; N, 12.83; O, 9.77; S, 9.79

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: M1001; M 1001; M-1001

IUPAC/Chemical Name: 3-((2-(Pyrrolidin-1-yl)phenyl)amino)benzo[d]isothiazole 1,1-dioxide


InChi Code: InChI=1S/C17H17N3O2S/c21-23(22)16-10-4-1-7-13(16)17(19-23)18-14-8-2-3-9-15(14)20-11-5-6-12-20/h1-4,7-10H,5-6,11-12H2,(H,18,19)


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 327.402 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: den Bakker HC, Manuel CS, Fortes ED, Wiedmann M, Nightingale KK. Genome sequencing identifies Listeria fleischmannii subsp. coloradonensis subsp. nov., isolated from a ranch. Int J Syst Evol Microbiol. 2013 Sep;63(Pt 9):3257-68. doi: 10.1099/ijs.0.048587-0. Epub 2013 Mar 22. PubMed PMID: 23524352.

2: Wang SL, Shieh ST, Pai CS. Production, purification and characterization of two proteinaceous hen-egg-white lysozyme inhibitors from Pseudomonas aeruginosa M-1001. Proc Natl Sci Counc Repub China B. 1995 Jul;19(3):166-75. PubMed PMID: 7480363.

3: Hukami K. [An attempt at training color vision defectives with Sanvista (M-1001)]. Nippon Ganka Gakkai Zasshi. 1966 Jun;70(6):589-92. Japanese. PubMed PMID: 5297148.

4: Perloff D, Sokolow M, Cowan R. Clinical relevance of ambulatory blood pressure measurements. Biotelem Patient Monit. 1981;8(1-2):67-80. PubMed PMID: 7295924.

5: Wang SL, Pai CS, Shieh ST. Production of lytic enzyme from Pseudomonas aeruginosa M-1001. Proc Natl Sci Counc Repub China B. 1995 Oct;19(4):216-24. PubMed PMID: 8742619.