WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585037
CAS#: 99258-56-7 (free base)
Description: Oxamisole is an immunoregulator that has immunorestorative effects on T-cells.
MedKoo Cat#: 585037
CAS#: 99258-56-7 (free base)
Chemical Formula: C15H20N2O2
Exact Mass: 260.1525
Molecular Weight: 260.337
Elemental Analysis: C, 69.20; H, 7.74; N, 10.76; O, 12.29
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 99258-55-6 (HCl); 99258-56-7 (free base)
Synonym: Oxamisole; Oxamisol; PR 879-317A
IUPAC/Chemical Name: Imidazo(1,2-a)pyridine, 2,3,5,6,7,8-hexahydro-8,8-dimethoxy-2-phenyl-
InChi Key: DWIKEPVFPTUJQU-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H20N2O2/c1-18-15(19-2)9-6-10-17-11-13(16-14(15)17)12-7-4-3-5-8-12/h3-5,7-8,13H,6,9-11H2,1-2H3
SMILES Code: COC1(OC)C2=NC(C3=CC=CC=C3)CN2CCC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 260.337 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Radov LA, Kamp D, Trusso LA, Sloane D, Julien RP, Clemens CM, Murray RJ. The immunological profile of a new immunomodulatory agent, oxamisole. Int J Immunopharmacol. 1988;10(5):609-18. PubMed PMID: 3263341.
2: Warren RP, Sidwell RW, Huffman JH, Call EW, Healey MC, Johnston AV, Radov LA, Murray RJ, Kinsolving CR. Effect of oxamisole on immune parameters of mice infected with murine hepatitis. Int J Immunopharmacol. 1990;12(6):625-30. PubMed PMID: 2177037.
3: Sidwell RW, Morrey JD, Okleberry KM, Burger RA, Warren RP. Immunomodulator effects on the Friend virus infection in genetically defined mice. Ann N Y Acad Sci. 1993 Jun 23;685:432-46. PubMed PMID: 8363251.
4: Sidwell RW, Huffman JH, Call EW, Warren RP, Radov LA, Murray RJ. Inhibition of murine hepatitis virus infections by the immunomodulator 2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo[1,2a]pyridine (PR-879-317A). Antimicrob Agents Chemother. 1987 Jul;31(7):1130-4. PubMed PMID: 2821891; PubMed Central PMCID: PMC174883.
5: Warren RP, Healey MC, Johnston AV, Sidwell RW, Radov LA, Murray RJ, Kinsolving CR. PR 879-317A enhances in vitro immune activity of peripheral blood mononuclear cells from patients with Down syndrome. Int J Immunopharmacol. 1987;9(8):919-26. PubMed PMID: 2962955.