Campestanol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585034

CAS#: 474-60-2

Description: Campestanol is a phytosterol found in vegetables, fruits, nuts, and seeds.


Chemical Structure

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Campestanol
CAS# 474-60-2

Theoretical Analysis

MedKoo Cat#: 585034
Name: Campestanol
CAS#: 474-60-2
Chemical Formula: C28H50O
Exact Mass: 402.3862
Molecular Weight: 402.707
Elemental Analysis: C, 83.51; H, 12.52; O, 3.97

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Campestanol

IUPAC/Chemical Name: 24alpha-Methyl-5alpha-cholestan-3beta-ol

InChi Key: ARYTXMNEANMLMU-ATEDBJNTSA-N

InChi Code: InChI=1S/C28H50O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h18-26,29H,7-17H2,1-6H3/t19-,20-,21+,22+,23+,24-,25+,26+,27+,28-/m1/s1

SMILES Code: CC(C)[C@H](C)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 402.707 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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1: Salen G, Xu G, Tint GS, Batta AK, Shefer S. Hyperabsorption and retention of campestanol in a sitosterolemic homozygote: comparison with her mother and three control subjects. J Lipid Res. 2000 Nov;41(11):1883-9. PubMed PMID: 11060358.

2: Xu G, Salen G, Tint GS, Batta AK, Shefer S. Campestanol (24-methyl-5alpha-cholestan-3beta-ol) absorption and distribution in New Zealand White rabbits: effect of dietary sitostanol. Metabolism. 1999 Mar;48(3):363-8. PubMed PMID: 10094114.

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4: Gylling H, Miettinen TA. Cholesterol reduction by different plant stanol mixtures and with variable fat intake. Metabolism. 1999 May;48(5):575-80. PubMed PMID: 10337856.

5: Connor WE, Lin DS, Pappu AS, Frohlich J, Gerhard G. Dietary sitostanol and campestanol: accumulation in the blood of humans with sitosterolemia and xanthomatosis and in rat tissues. Lipids. 2005 Sep;40(9):919-23. PubMed PMID: 16331855.

6: Jiang L, Zhao X, Xu J, Li C, Yu Y, Wang W, Zhu L. The Protective Effect of Dietary Phytosterols on Cancer Risk: A Systematic Meta-Analysis. J Oncol. 2019 Jun 23;2019:7479518. doi: 10.1155/2019/7479518. eCollection 2019. Review. PubMed PMID: 31341477; PubMed Central PMCID: PMC6612402.

7: Merkens LS, Myrie SB, Steiner RD, Mymin D. Sitosterolemia. 2013 Apr 4 [updated 2018 May 17]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019. Available from http://www.ncbi.nlm.nih.gov/books/NBK131810/ PubMed PMID: 23556150.

8: Kircher HW, Rosenstein FU. Purification of campesterol and preparation of 7-dehydrocampesterol, 7-campestenol and campestanol. Lipids. 1974 May;9(5):333-7. PubMed PMID: 4857275.

9: Wocheslander S, Eisenreich W, Scholz B, Lander V, Engel KH. Identification of Acyl Chain Oxidation Products upon Thermal Treatment of a Mixture of Phytosteryl/-stanyl Linoleates. J Agric Food Chem. 2016 Dec 7;64(48):9214-9223. Epub 2016 Nov 29. PubMed PMID: 27933991.

10: Gylling H, Simonen P, Kaipiainen L, Wester I. Methodological aspects of phytosterol measurements in biological samples. Curr Med Chem. 2018 Jul 13. doi: 10.2174/0929867325666180713160330. [Epub ahead of print] PubMed PMID: 30009697.

11: Schött HF, Krautbauer S, Höring M, Liebisch G, Matysik S. A Validated, Fast Method for Quantification of Sterols and Gut Microbiome Derived 5α/β-Stanols in Human Feces by Isotope Dilution LC-High-Resolution MS. Anal Chem. 2018 Jul 17;90(14):8487-8494. doi: 10.1021/acs.analchem.8b01278. Epub 2018 Jul 3. PubMed PMID: 29920210.

12: Plat J, Mensink RP. Vegetable oil based versus wood based stanol ester mixtures: effects on serum lipids and hemostatic factors in non-hypercholesterolemic subjects. Atherosclerosis. 2000 Jan;148(1):101-12. PubMed PMID: 10580176.

13: Cusack LK, Fernandez ML, Volek JS. The food matrix and sterol characteristics affect the plasma cholesterol lowering of phytosterol/phytostanol. Adv Nutr. 2013 Nov 6;4(6):633-43. doi: 10.3945/an.113.004507. eCollection 2013 Nov. Review. PubMed PMID: 24228192; PubMed Central PMCID: PMC3823509.

14: Nakajima N, Fujioka S, Tanaka T, Takatsuto S, Yoshida S. Biosynthesis of cholestanol in higher plants. Phytochemistry. 2002 Jun;60(3):275-9. PubMed PMID: 12031446.

15: Sanders DJ, Minter HJ, Howes D, Hepburn PA. The safety evaluation of phytosterol esters. Part 6. The comparative absorption and tissue distribution of phytosterols in the rat. Food Chem Toxicol. 2000 Jun;38(6):485-91. PubMed PMID: 10828500.

16: Fibigr J, Šatínský D, Solich P. A UHPLC method for the rapid separation and quantification of phytosterols using tandem UV/Charged aerosol detection - A comparison of both detection techniques. J Pharm Biomed Anal. 2017 Jun 5;140:274-280. doi: 10.1016/j.jpba.2017.03.057. Epub 2017 Mar 30. PubMed PMID: 28384622.

17: Ammar S, Kelebek H, Zribi A, Abichou M, Selli S, Bouaziz M. LC-DAD/ESI-MS/MS characterization of phenolic constituents in Tunisian extra-virgin olive oils: Effect of olive leaves addition on chemical composition. Food Res Int. 2017 Oct;100(Pt 3):477-485. doi: 10.1016/j.foodres.2016.11.001. Epub 2016 Nov 5. PubMed PMID: 28964371.

18: Noguchi T, Fujioka S, Takatsuto S, Sakurai A, Yoshida S, Li J, Chory J. Arabidopsis det2 is defective in the conversion of (24R)-24-methylcholest-4-En-3-one to (24R)-24-methyl-5alpha-cholestan-3-one in brassinosteroid biosynthesis. Plant Physiol. 1999 Jul;120(3):833-40. PubMed PMID: 10398719; PubMed Central PMCID: PMC59322.

19: Rudzińska M, Przybylski R, Wąsowicz E. Degradation of phytosterols during storage of enriched margarines. Food Chem. 2014 Jan 1;142:294-8. doi: 10.1016/j.foodchem.2013.07.041. Epub 2013 Jul 17. PubMed PMID: 24001844.

20: Xu G, Salen G, Shefer S, Tint GS, Nguyen LB, Batta AK, Pcolinsky M. Plant stanol fatty acid esters inhibit cholesterol absorption and hepatic hydroxymethyl glutaryl coenzyme A reductase activity to reduce plasma levels in rabbits. Metabolism. 2001 Sep;50(9):1106-12. PubMed PMID: 11555847.