WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565675
Description: 2-Ethoxystypandrone is a novel potent natural stat3 signaling inhibitor from polygonum cuspidatum, inhibiting cell growth and inducing apoptosis of hcc cells and hcc cancer stem cells.
MedKoo Cat#: 565675
Chemical Formula: C15H14O5
Exact Mass: 274.0841
Molecular Weight: 274.272
Elemental Analysis: C, 65.69; H, 5.15; O, 29.17
This product is not in stock, which may be available by custom synthesis.
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IUPAC/Chemical Name: 6-Acetyl-5-hydroxy-2-ethoxy-7-methylnaphthalene-1,4-dione
InChi Key: HHPDGVKSXLTKLE-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14O5/c1-4-20-11-6-10(17)13-9(14(11)18)5-7(2)12(8(3)16)15(13)19/h5-6,19H,4H2,1-3H3
SMILES Code: O=C1C(OCC)=CC(C2=C1C=C(C)C(C(C)=O)=C2O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 274.272 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Li W, Zhang Q, Chen K, Sima Z, Liu J, Yu Q, Liu J. 2-Ethoxystypandrone, a novel small-molecule STAT3 signaling inhibitor from Polygonum cuspidatum, inhibits cell growth and induces apoptosis of HCC cells and HCC Cancer stem cells. BMC Complement Altern Med. 2019 Feb 1;19(1):38. doi: 10.1186/s12906-019-2440-9. PubMed PMID: 30709346; PubMed Central PMCID: PMC6359800.