3'-Bromorubrolide F

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MedKoo CAT#: 565647

CAS#: 1403355-52-1

Description: 3'-Bromorubrolide F is a putative natural allosteric modulator of human hsp90α conformational dynamics by allosteric ligand interaction at the c-terminal domain site 2


Chemical Structure

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3'-Bromorubrolide F
CAS# 1403355-52-1

Theoretical Analysis

MedKoo Cat#: 565647
Name: 3'-Bromorubrolide F
CAS#: 1403355-52-1
Chemical Formula: C17H11BrO4
Exact Mass: 357.98
Molecular Weight: 359.175
Elemental Analysis: C, 56.85; H, 3.09; Br, 22.25; O, 17.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 3'-Bromorubrolide F; 3-Bromorubrolide E; SANC309; SANC 309; SANC-309

IUPAC/Chemical Name: (5{Z})-4-(3-Bromo-4-hydroxyphenyl)-5-[(4-hydroxyphenyl)methylidene]furan-2-one

InChi Key: IXURNKCVCIQLGL-APSNUPSMSA-N

InChi Code: InChI=1S/C17H11BrO4/c18-14-8-11(3-6-15(14)20)13-9-17(21)22-16(13)7-10-1-4-12(19)5-2-10/h1-9,19-20H/b16-7-

SMILES Code: O=C(C=C/1C2=CC=C(O)C(Br)=C2)OC1=C/C3=CC=C(O)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 359.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Penkler DL, Tastan Bishop Ö. Modulation of Human Hsp90α Conformational Dynamics by Allosteric Ligand Interaction at the C-Terminal Domain. Sci Rep. 2019 Feb 7;9(1):1600. doi: 10.1038/s41598-018-35835-0. PubMed PMID: 30733455; PubMed Central PMCID: PMC6367426.

2: Sikorska J, Parker-Nance S, Davies-Coleman MT, Vining OB, Sikora AE, McPhail KL. Antimicrobial rubrolides from a South African species of Synoicum tunicate. J Nat Prod. 2012 Oct 26;75(10):1824-7. doi: 10.1021/np300580z. Epub 2012 Oct 2. PubMed PMID: 23030848; PubMed Central PMCID: PMC3549467.