AM-92016 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555585

CAS#: 133229-11-5 (HCl)

Description: AM-92016 is an oxypropanolamine analogue of sotalol, has been shown to possess Class III anti-arrhythmic properties in-vitro at concentrations showing 1000 times more potency than sotalol. AM 92016 exhibited proarrhythmic rather than antiarrhythmic activity when administered in-vivo to either guinea-pigs or pigs.

Chemical Structure

AM-92016 HCl
CAS# 133229-11-5 (HCl)

Theoretical Analysis

MedKoo Cat#: 555585
Name: AM-92016 HCl
CAS#: 133229-11-5 (HCl)
Chemical Formula: C19H25Cl3N2O4S
Exact Mass:
Molecular Weight: 483.829
Elemental Analysis: C, 47.17; H, 5.21; Cl, 21.98; N, 5.79; O, 13.23; S, 6.63

Price and Availability

Size Price Availability Quantity
25.0mg USD 250.0 2 Weeks
50.0mg USD 450.0 2 Weeks
100.0mg USD 750.0 2 Weeks
200.0mg USD 1250.0 2 Weeks
500.0mg USD 1950.0 2 Weeks
1.0g USD 3250.0 2 Weeks
2.0g USD 5850.0 2 Weeks
Bulk inquiry

Related CAS #: 133229-23-9 (free base)   133229-11-5 (HCl)    

Synonym: AM-92016 HCl; AM 92016 HCl; AM92016 HCl; AM-92016 hydrochloride

IUPAC/Chemical Name: N-(4-(3-((3,4-dichlorophenethyl)(methyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide hydrochloride


InChi Code: InChI=1S/C19H24Cl2N2O4S.ClH/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26;/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3;1H

SMILES Code: OC(CN(C)CCC1=CC=C(Cl)C(Cl)=C1)COC2=CC=C(NS(=O)(C)=O)C=C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 483.829 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Katsuki H, Shinohara A, Fujimoto S, Kume T, Akaike A. Tetraethylammonium
exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures. Eur J
Pharmacol. 2005 Jan 31;508(1-3):85-91. Epub 2005 Jan 6. PubMed PMID: 15680257.

2: Hagerty MJ, Wainwright CL, Kane KA. The in-vivo cardiovascular effects of a
putative class III anti-arrhythmic drug, AM 92016. J Pharm Pharmacol. 1996
Apr;48(4):417-21. PubMed PMID: 8794994.