WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565586


Description: YZ129 is a novel hsp90 inhibitor, targeting the calcineurin-nfat signaling and hsp90 client network for glioblastoma (gbm) therapy

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 565586
Name: YZ129
Chemical Formula: C19H12N2O2
Exact Mass: 300.0899
Molecular Weight: 300.317
Elemental Analysis: C, 75.99; H, 4.03; N, 9.33; O, 10.65

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: YZ129; YZ 129; YZ-129

IUPAC/Chemical Name: 4-(Isoquinolin-6-ylamino)naphthalene-1,2-dione


InChi Code: InChI=1S/C19H12N2O2/c22-18-10-17(15-3-1-2-4-16(15)19(18)23)21-14-6-5-13-11-20-8-7-12(13)9-14/h1-11,21H

SMILES Code: O=C1C(C=C(NC2=CC3=C(C=NC=C3)C=C2)C4=C1C=CC=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 300.317 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Liu Z, Li H, He L, Xiang Y, Tian C, Li C, Tan P, Jing J, Tian Y, Du L, Huang Y, Han L, Li M, Zhou Y. Discovery of Small-Molecule Inhibitors of the HSP90-Calcineurin-NFAT Pathway against Glioblastoma. Cell Chem Biol. 2019 Mar 21;26(3):352-365.e7. doi: 10.1016/j.chembiol.2018.11.009. Epub 2019 Jan 10. PubMed PMID: 30639261; PubMed Central PMCID: PMC6430684.