WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565557
CAS#: 2089-82-9
Description: sAJM589 suppressed cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage independent growth of Raji cells. Disruption of the Myc-Max interaction by sAJM589 reduced Myc protein levels, possibly by promoting ubiquitination and degradation of Myc. sAJM589 may be a basis for the development of potential inhibitors of Myc-dependent cell growth.
MedKoo Cat#: 565557
Name: sAJM589
CAS#: 2089-82-9
Chemical Formula: C16H10N2O
Exact Mass: 246.0793
Molecular Weight: 246.269
Elemental Analysis: C, 78.03; H, 4.09; N, 11.38; O, 6.50
This product is not in stock, which may be available by custom synthesis.
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Synonym: sAJM589; sAJM 589; sAJM-589
IUPAC/Chemical Name: Benzo[a]phenazin-5-ol
InChi Key: WZBDRAAGHRCRKM-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H10N2O/c19-15-9-14-16(11-6-2-1-5-10(11)15)18-13-8-4-3-7-12(13)17-14/h1-9,19H
SMILES Code: OC1=CC2=NC3=CC=CC=C3N=C2C4=CC=CC=C41
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 246.269 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Choi SH, Mahankali M, Lee SJ, Hull M, Petrassi HM, Chatterjee AK, Schultz PG, Jones KA, Shen W. Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule. ACS Chem Biol. 2017 Nov 17;12(11):2715-2719. doi: 10.1021/acschembio.7b00799. Epub 2017 Oct 11. PubMed PMID: 28976731.
