NecroX-7

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MedKoo CAT#: 565526

CAS#: 1120333-38-1

Description: NecroX-7 is a inhibitor of osteoclast differentiation by suppressing nf-kappab activity and c-fos expression, inhibiting oxidative stress-induced necrosis in macrophages


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-28. Prices are subject to change without notice.

NecroX-7 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565526
Name: NecroX-7
CAS#: 1120333-38-1
Chemical Formula: C25H32N4O4S2
Exact Mass: 516.1865
Molecular Weight: 516.675
Elemental Analysis: C, 58.12; H, 6.24; N, 10.84; O, 12.39; S, 12.41


Synonym: NecroX-7; NecroX 7; NecroX7

IUPAC/Chemical Name: 4-((7-((1-(Methylsulfonyl)piperidin-4-yl)amino)-2-phenyl-1H-indol-5-yl)methyl)thiomorpholine 1,1-dioxide

InChi Key: OXROWZRDUZOTSG-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H32N4O4S2/c1-34(30,31)29-9-7-22(8-10-29)26-24-16-19(18-28-11-13-35(32,33)14-12-28)15-21-17-23(27-25(21)24)20-5-3-2-4-6-20/h2-6,15-17,22,26-27H,7-14,18H2,1H3

SMILES Code: O=S(N1CCC(NC2=CC(CN3CCS(CC3)(=O)=O)=CC4=C2NC(C5=CC=CC=C5)=C4)CC1)(C)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Im KI, Nam YS, Kim N, Song Y, Lee ES, Lim JY, Jeon YW, Cho SG. Regulation of HMGB1 release protects chemoradiotherapy-associated mucositis. Mucosal Immunol. 2019 Jan 15. doi: 10.1038/s41385-019-0132-x. [Epub ahead of print] PubMed PMID: 30647411.

2: Hwang IC, Kim JY, Kim JH, Lee JE, Seo JY, Lee JW, Park J, Yang HM, Kim SH, Cho HJ, Kim HS. Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia-Reperfusion Injury. Hypertension. 2018 Jun;71(6):1143-1155. doi: 10.1161/HYPERTENSIONAHA.117.09405. Epub 2018 Apr 16. PubMed PMID: 29661840; PubMed Central PMCID: PMC5959205.

3: Lee JH, Park KM, Lee YJ, Kim JH, Kim SH. A New Chemical Compound, NecroX-7, Acts as a Necrosis Modulator by Inhibiting High-Mobility Group Box 1 Protein Release During Massive Ischemia-Reperfusion Injury. Transplant Proc. 2016 Dec;48(10):3406-3414. doi: 10.1016/j.transproceed.2016.09.046. PubMed PMID: 27931589.

4: Biswas SK. NecroX-7 may appear as a new molecule to stabilize atherosclerotic plaques. Atherosclerosis. 2016 Sep;252:190-191. doi: 10.1016/j.atherosclerosis.2016.07.917. Epub 2016 Jul 25. PubMed PMID: 27477187.

5: Grootaert MOJ, Schrijvers DM, Van Spaendonk H, Breynaert A, Hermans N, Van Hoof VO, Takahashi N, Vandenabeele P, Kim SH, De Meyer GRY, Martinet W. NecroX-7 reduces necrotic core formation in atherosclerotic plaques of Apoe knockout mice. Atherosclerosis. 2016 Sep;252:166-174. doi: 10.1016/j.atherosclerosis.2016.06.045. Epub 2016 Jul 2. PubMed PMID: 27425215.

6: Degterev A, Linkermann A. Generation of small molecules to interfere with regulated necrosis. Cell Mol Life Sci. 2016 Jun;73(11-12):2251-67. doi: 10.1007/s00018-016-2198-x. Epub 2016 Apr 5. Review. PubMed PMID: 27048812.

7: Jin SA, Kim SK, Seo HJ, Jeong JY, Ahn KT, Kim JH, Choi DE, Park JH, Lee JH, Choi SW, Seong IW, Kim SH, Suh KS, Jeong JO. Beneficial Effects of Necrosis Modulator, Indole Derivative NecroX-7, on Renal Ischemia-Reperfusion Injury in Rats. Transplant Proc. 2016 Jan-Feb;48(1):199-204. doi: 10.1016/j.transproceed.2015.12.018. PubMed PMID: 26915868.

8: Im KI, Kim N, Lim JY, Nam YS, Lee ES, Kim EJ, Kim HJ, Kim SH, Cho SG. The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release. J Immunol. 2015 Jun 1;194(11):5223-32. doi: 10.4049/jimmunol.1402609. Epub 2015 Apr 24. PubMed PMID: 25911749; PubMed Central PMCID: PMC4432727.

9: Chung HK, Kim YK, Park JH, Ryu MJ, Chang JY, Hwang JH, Lee CH, Kim SH, Kim HJ, Kweon GR, Kim KS, Shong M. The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation. Liver Int. 2015 Apr;35(4):1341-53. doi: 10.1111/liv.12741. Epub 2015 Jan 10. PubMed PMID: 25443620.

10: Park JH, Seo KS, Tadi S, Ahn BH, Lee JU, Heo JY, Han J, Song MS, Kim SH, Yim YH, Choi HS, Shong M, Kweon G. An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice. Antioxid Redox Signal. 2013 May 10;18(14):1713-22. doi: 10.1089/ars.2012.4677. Epub 2012 Dec 19. PubMed PMID: 23121402; PubMed Central PMCID: PMC3619205.

11: Kim HJ, Yoon KA, Lee MK, Kim SH, Lee IK, Kim SY. A novel small molecule, NecroX-7, inhibits osteoclast differentiation by suppressing NF-κB activity and c-Fos expression. Life Sci. 2012 Nov 2;91(19-20):928-34. doi: 10.1016/j.lfs.2012.09.009. Epub 2012 Sep 20. PubMed PMID: 23000100.

12: Park J, Park E, Ahn BH, Kim HJ, Park JH, Koo SY, Kwak HS, Park HS, Kim DW, Song M, Yim HJ, Seo DO, Kim SH. NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats. Toxicol Appl Pharmacol. 2012 Aug 15;263(1):1-6. doi: 10.1016/j.taap.2012.05.014. Epub 2012 May 31. PubMed PMID: 22659508.

13: Lee DW, Lee TK, Cho IS, Park HE, Jin S, Cho HJ, Kim SH, Oh S, Kim HS. Creation of myocardial fibrosis by transplantation of fibroblasts primed with survival factors. Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H1004-14. doi: 10.1152/ajpheart.00156.2011. Epub 2011 Jun 17. PubMed PMID: 21685267.

14: Choi JM, Park KM, Kim SH, Hwang DW, Chon SH, Lee JH, Lee SY, Lee YJ. Effect of necrosis modulator necrox-7 on hepatic ischemia-reperfusion injury in beagle dogs. Transplant Proc. 2010 Nov;42(9):3414-21. doi: 10.1016/j.transproceed.2010.08.050. PubMed PMID: 21094788.