Sphynolactone-7
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565473

CAS#: 2305752-57-0

Description: Sphynolactone-7 is a novel selective and highly potent strigolactone agonist, activating a high-affinity strigolactone receptor shhtl7 to provoke striga germination with potency in the femtomolar range.


Chemical Structure

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Sphynolactone-7
CAS# 2305752-57-0

Theoretical Analysis

MedKoo Cat#: 565473
Name: Sphynolactone-7
CAS#: 2305752-57-0
Chemical Formula: C20H26N2O7S
Exact Mass: 438.15
Molecular Weight: 438.500
Elemental Analysis: C, 54.78; H, 5.98; N, 6.39; O, 25.54; S, 7.31

Price and Availability

Size Price Availability Quantity
5mg USD 265 2 weeks
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Synonym: SPL7; Sphynolactone-7; Sphynolactone 7; Sphynolactone7

IUPAC/Chemical Name: 4-Methyl-5-oxo-2,5-dihydrofuran-2-yl 4-((4-butoxyphenyl)sulfonyl)piperazine-1-carboxylate

InChi Key: GGAPQPVAXJSNFU-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H26N2O7S/c1-3-4-13-27-16-5-7-17(8-6-16)30(25,26)22-11-9-21(10-12-22)20(24)29-18-14-15(2)19(23)28-18/h5-8,14,18H,3-4,9-13H2,1-2H3

SMILES Code: O=C(N1CCN(S(=O)(C2=CC=C(OCCCC)C=C2)=O)CC1)OC(C=C3C)OC3=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Biological target: Sphynolactone-7 selectively binds to ShHTL7 (IC50 = 0.31 µM) over ShHTL2-6, ShHTL9-10, and the strigolactone receptor AtD14 at 10 µM but does inhibit ShHTL8 and ShHTL11 (IC50s = 1.2 and 7.8 µM, respectively).
In vitro activity: To be determined
In vivo activity: This study demonstrated that sphynolactone-7 is effective for reducing the parasitic plant Striga parasitism without impinging on host strigolactone-related processes. Sphynolactone-7 provoked Striga germination with potency in the femtomolar range. Reference: Science. 2018 Dec 14;362(6420):1301-1305. https://pubmed.ncbi.nlm.nih.gov/30545887/

Preparing Stock Solutions

The following data is based on the product molecular weight 438.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C, Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. doi: 10.1126/science.aau5445. PMID: 30545887.
In vitro protocol: To be determined
In vivo protocol: 1. Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C, Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y. A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. doi: 10.1126/science.aau5445. PMID: 30545887.

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1: Uraguchi D, Kuwata K, Hijikata Y, Yamaguchi R, Imaizumi H, Am S, Rakers C,
Mori N, Akiyama K, Irle S, McCourt P, Kinoshita T, Ooi T, Tsuchiya Y. A
femtomolar-range suicide germination stimulant for the parasitic plant Striga
hermonthica. Science. 2018 Dec 14;362(6420):1301-1305. doi:
10.1126/science.aau5445. PubMed PMID: 30545887.