Alprenoxime

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573750

CAS#: 118552-63-9

Description: Alprenoxime is the ketoxime precursor of alprenolol -- an antiglaucoma drug.


Chemical Structure

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Alprenoxime
CAS# 118552-63-9

Theoretical Analysis

MedKoo Cat#: 573750
Name: Alprenoxime
CAS#: 118552-63-9
Chemical Formula: C15H22N2O2
Exact Mass: 262.1681
Molecular Weight: 262.35
Elemental Analysis: C, 68.67; H, 8.45; N, 10.68; O, 12.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Alprenoxime

IUPAC/Chemical Name: 2-Propanone, 1-((1-methylethyl)amino)-3-(2-(2-propenyl)phenoxy)-, oxime

InChi Key: XFQFSSGNEFUEPA-VKAVYKQESA-N

InChi Code: 1S/C15H22N2O2/c1-4-7-13-8-5-6-9-15(13)19-11-14(17-18)10-16-12(2)3/h4-6,8-9,12,16,18H,1,7,10-11H2,2-3H3/b17-14-

SMILES Code: C(\C(COc1c(cccc1)CC=C)=N\O)NC(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 262.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Bodor N, Prokai L, Wu WM, Somogyi G, Farag H. Sequential bioactivation of methoxime analogs of beta-adrenergic antagonists in the eye. J Ocul Pharmacol Ther. 1995 Fall;11(3):305-18. PubMed PMID: 8590263.

2: Polgar P, Bodor N. Minimal cardiac electrophysiological activity of alprenoxime, a site-activated ocular beta-blocker, in dogs. Life Sci. 1995;56(14):1207-13. PubMed PMID: 7475898.

3: Bodor N, Elkoussi A. Improved delivery through biological membranes. LVI. Pharmacological evaluation of alprenoxime--a new potential antiglaucoma agent. Pharm Res. 1991 Nov;8(11):1389-95. PubMed PMID: 1798675.