WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573746
Description: 5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.
MedKoo Cat#: 573746
Name: 5-trans-Prostaglandin E2
Chemical Formula: C20H32O5
Exact Mass: 352.225
Molecular Weight: 352.47
Elemental Analysis: C, 68.15; H, 9.15; O, 22.70
Synonym: 5,6-trans-Dinoprostone, 5,6-trans-PGE2, 5-trans-PGE2, 5-trans-Prostaglandin E2, Alprostadil impurity H, trans-Dinoprostone
IUPAC/Chemical Name: (E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid
InChi Key: XEYBRNLFEZDVAW-BRNHSORCSA-N
InChi Code: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+/t15-,16+,17+,19+/m0/s1
SMILES Code: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C/CCCC(=O)O)O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 352.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: McCluskey SV, Kirkham K, Munson JM. Stability of Alprostadil in 0.9% Sodium Chloride Stored in Polyvinyl Chloride Containers. Int J Pharm Compd. 2017 Mar-Apr;21(2):150-153. PubMed PMID: 28346210.
2: Ossorio-García L, Jiménez-Gallo D, Arjona-Aguilera C, Linares-Barrios M. Multimodal Treatment of Calciphylaxis With Sodium Thiosulfate, Alprostadil, and Hyperbaric Oxygen Therapy. Actas Dermosifiliogr. 2016 Oct;107(8):695-7. doi: 10.1016/j.ad.2016.04.004. Epub 2016 May 18. English, Spanish. PubMed PMID: 27208908.
3: Chen Y, Wan JX, Jiang DW, Fu BB, Cui J, Li GF. [Clinical efficacy and safety of sequential treatment with alprostadil and beraprost sodium for chronic renal failure induced by chronic glomerulonephritis]. Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1521-4. Chinese. PubMed PMID: 24144760.