WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 207105
CAS#: 1332881-26-1 (free base)
Description: ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against panels of melanoma and prostate cancer cell lines, is orally bioavailable, and strongly suppress melanoma tumors in vivo. ABI-231 holds great promise as a new generation of orally available tubulin inhibitor.
MedKoo Cat#: 207105
Name: ABI-231
CAS#: 1332881-26-1 (free base)
Chemical Formula: C21H19N3O4
Exact Mass: 377.1376
Molecular Weight: 377.4
Elemental Analysis: C, 66.83; H, 5.07; N, 11.13; O, 16.96
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Related CAS #: 2635953-17-0 (HCl) 1332881-26-1 (free base)
Synonym: ABI-231; ABI 231; ABI231; Compound 17ya; Sabizabulin; VERU 111;
IUPAC/Chemical Name: (2-(1H-indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl)methanone
InChi Key: WQGVHOVEXMOLOK-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N3O4/c1-26-17-8-12(9-18(27-2)20(17)28-3)19(25)16-11-23-21(24-16)14-10-22-15-7-5-4-6-13(14)15/h4-11,22H,1-3H3,(H,23,24)
SMILES Code: O=C(C1=CC(OC)=C(OC)C(OC)=C1)C2=CNC(C3=CNC4=CC=CC=C43)=N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 377.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Wang Q, Arnst KE, Wang Y, Kumar G, Ma D, White SW, Miller DD, Li W, Li W.
Structure-Guided Design, Synthesis, and Biological Evaluation of
(2-(1H-Indol-3-yl)-1H-imidazol-4-yl)(3,4,5-trimethoxyphenyl) Methanone (ABI-231)
Analogues Targeting the Colchicine Binding Site in Tubulin. J Med Chem. 2019 Jul
12. doi: 10.1021/acs.jmedchem.9b00706. [Epub ahead of print] PubMed PMID:
31251599.
