WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573729
CAS#: 486-16-8
Description: Carbinoxamine is an antihistamine and anticholinergic agent. It is used for hay fever, vasomotor rhinitis, mild urticaria, angioedema, dermatographism and allergic conjunctivitis. Carbinoxamine is a histamine antagonist, specifically an H1-antagonist.
MedKoo Cat#: 573729
Name: Carbinoxamine
CAS#: 486-16-8
Chemical Formula: C16H19ClN2O
Exact Mass: 290.1186
Molecular Weight: 290.79
Elemental Analysis: C, 66.09; H, 6.59; Cl, 12.19; N, 9.63; O, 5.50
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: (+-)-Carbinoxamine, Allergefon, Carbinoxamine, Paracarbinoxamine
IUPAC/Chemical Name: Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl- (9CI)
InChi Key: OJFSXZCBGQGRNV-UHFFFAOYSA-N
InChi Code: 1S/C16H19ClN2O/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13/h3-10,16H,11-12H2,1-2H3
SMILES Code: n1c([C@@H](c2ccc(cc2)Cl)OCCN(C)C)cccc1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 290.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Xu W, Xia S, Pu J, Wang Q, Li P, Lu L, Jiang S. The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses. Front Microbiol. 2018 Nov 6;9:2643. doi: 10.3389/fmicb.2018.02643. eCollection 2018. PubMed PMID: 30459739; PubMed Central PMCID: PMC6232386.
2: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501270/ PubMed PMID: 30000329.
3: Harikrishnan A, Sanjeevi J, Ramanathan CR. The cooperative effect of Lewis pairs in the Friedel-Crafts hydroxyalkylation reaction: a simple and effective route for the synthesis of (±)-carbinoxamine. Org Biomol Chem. 2015 Mar 28;13(12):3633-47. doi: 10.1039/c4ob02597k. PubMed PMID: 25672597.
