WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585009
CAS#: 54708-51-9
Description: PZ 177 has analgesic, anti-inflammatory and mild central depressive actions.
MedKoo Cat#: 585009
Name: PZ 177
CAS#: 54708-51-9
Chemical Formula: C13H14ClN3O2
Exact Mass: 279.0775
Molecular Weight: 279.724
Elemental Analysis: C, 55.82; H, 5.04; Cl, 12.67; N, 15.02; O, 11.44
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: PZ 177; PZ177; PZ-177
IUPAC/Chemical Name: 1H-Pyrazole-3-carboxamide, 1-(3-chlorophenyl)-5-methoxy-N,N-dimethyl-
InChi Key: XVCQBERSJBUIEB-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H14ClN3O2/c1-16(2)13(18)11-8-12(19-3)17(15-11)10-6-4-5-9(14)7-10/h4-8H,1-3H3
SMILES Code: O=C(C1=NN(C2=CC=CC(Cl)=C2)C(OC)=C1)N(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 279.724 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Tsurumi K, Go K, Fujimura H. [Acute toxicity and the central effect of 1-(m-chlorophenyl)-3-N,N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1976;72(1):31-9. Japanese. PubMed PMID: 986348.
2: Tsurumi K, Abe A, Fujimura H, Asai H, Nagasaka M. [General pharmacological actions of l-(m-chlorophenyl)-3-N,N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1976;72(1):41-52. Japanese. PubMed PMID: 986349.
3: Tsurumi K, Abe A, Shibuya T, Fujimura H. [Anti-edematous action of 1-(m-chlorophenyl)-3-N, N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1975 Nov;71(8):833-41. Japanese. PubMed PMID: 1240833.
4: Morikawa M, Inoue M, Yoshida S, Tsuboi M. Effect of 1-(m-chlorophenyl)-3-N,N-dimethyl-carbamoyl-5-methoxypyrazole (PZ-177) on drug-metabolizing enzyme on rat liver. Jpn J Pharmacol. 1976 Oct;26(5):593-8. PubMed PMID: 1087357.
5: Tsurumi K, Mirii I, Nozaki M, Fujimura H. [Anti-inflammatory, analgesic and antipyretic actions of 1-(m-chlorophenyl)-3-N, N-dimethylcarbamoyl-5-methoxypyrazole (PZ-177)]. Nihon Yakurigaku Zasshi. 1975 Nov;71(8):843-56. Japanese. PubMed PMID: 1082832.
6: Sugiura S, Izumi K, Kato K, Hori M. [Studies on syntheses of pyrazolone and pyrazole derivatives. VI. Isolation and identification of metabolites in rabbit urine dosing 1-(3-chlorophenyl)-3-(N,N-dimethylcarbamoyl)-5-methoxypyrazole (author's transl)]. Yakugaku Zasshi. 1981 Mar;101(3):266-70. Japanese. PubMed PMID: 7299639.
