WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555569
Description: SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. TGR5 contributes to hepatic cystogenesis by increasing cAMP and enhancing cholangiocyte proliferation; our data suggest that a TGR5 antagonist alone or concurrently with somatostatin receptor agonists represents a potential therapeutic approach in polycystic liver disease
MedKoo Cat#: 555569
Chemical Formula: C14H13ClN2O4S
Exact Mass: 340.0285
Molecular Weight: 340.778
Elemental Analysis: C, 49.34; H, 3.85; Cl, 10.40; N, 8.22; O, 18.78; S, 9.41
Synonym: SBI-115; SBI 115; SBI115;
IUPAC/Chemical Name: 4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester
InChi Key: IJPXOPBVXVPPEW-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H13ClN2O4S/c1-3-22(19,20)14-16-8-11(15)12(17-14)13(18)21-10-6-4-5-9(2)7-10/h4-8H,3H2,1-2H3
SMILES Code: O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 340.778 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Masyuk TV, Masyuk AI, Lorenzo Pisarello M, Howard BN, Huang BQ, Lee PY, Fung
X, Sergienko E, Ardecky RJ, Chung TDY, Pinkerton AB, LaRusso NF. TGR5 contributes
to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic
adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct;66(4):1197-1218. doi:
10.1002/hep.29284. Epub 2017 Aug 26. PubMed PMID: 28543567; PubMed Central PMCID: