Datelliptium chloride
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MedKoo CAT#: 330195

CAS#: 105118-14-7 (chloride)

Description: Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride showed anti-tumor activities.


Chemical Structure

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Datelliptium chloride
CAS# 105118-14-7 (chloride)

Theoretical Analysis

MedKoo Cat#: 330195
Name: Datelliptium chloride
CAS#: 105118-14-7 (chloride)
Chemical Formula: C23H28ClN3O
Exact Mass:
Molecular Weight: 397.947
Elemental Analysis: C, 69.42; H, 7.09; Cl, 8.91; N, 10.56; O, 4.02

Price and Availability

Size Price Availability Quantity
50.0mg USD 550.0 2 Weeks
100.0mg USD 950.0 2 Weeks
200.0mg USD 1650.0 2 Weeks
500.0mg USD 2450.0 2 Weeks
1.0g USD 3650.0 2 Weeks
2.0g USD 5450.0 2 Weeks
5.0g USD 9950.0 2 Weeks
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Related CAS #: 81531-57-9 (cation)   105118-14-7 (chloride)   81531-58-0 (acetate)   157000-76-5 (chloride HCl)   958863-79-1 (mesylate)    

Synonym: Datelliptium chloride; SR 95156A; SR95156A; SR-95156A; SR 95156; SR95156; SR-95156; NSC 311152; NSC-311152; NSC311152;

IUPAC/Chemical Name: 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium chloride

InChi Key: UCICRVXYPSKKJK-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H27N3O.ClH/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23;/h7-10,13-14,27H,5-6,11-12H2,1-4H3;1H

SMILES Code: CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 397.947 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kriaa W, Sghaier-Hammami B, Masmoudi-Allouche F, Benjemaa-Masmoudi R, Drira N.
The date palm (Phoenix dactylifera L.) micropropagation using completely mature
female flowers. C R Biol. 2012 Mar;335(3):194-204. doi:
10.1016/j.crvi.2012.01.005. Epub 2012 Mar 15. PubMed PMID: 22464427.

2: Djuric Z, Everett CK, Valeriote FA. DNA damage and cytotoxicity in L1210 cells
by ellipticine and a structural analogue,
N-2-(diethylaminoethyl)-9-hydroxyellipticinium chloride. Cancer Res. 1992 Mar
15;52(6):1515-9. PubMed PMID: 1540960.

3: Khayat D, Borel C, Azab M, Paraisot D, Malaurie E, Bouloux C, Weil M. Phase I
study of Datelliptium chloride, hydrochloride given by 24-h continuous
intravenous infusion. Cancer Chemother Pharmacol. 1992;30(3):226-8. PubMed PMID:
1628372.

4: Mucci-LoRusso P, Polin L, Biernat LA, Valeriote FA, Corbett TH. Activity of
datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest
New Drugs. 1990 Aug;8(3):253-61. PubMed PMID: 2177044.

5: Multon E, Riou JF, LeFevre D, Ahomadegbe JC, Riou G. Topoisomerase II-mediated
DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
Biochem Pharmacol. 1989 Jul 1;38(13):2077-86. PubMed PMID: 2544183.

6: Auclair C, Pierre A, Voisin E, Pepin O, Cros S, Colas C, Saucier JM,
Verschuere B, Gros P, Paoletti C. Physicochemical and pharmacological properties
of the antitumor ellipticine derivative 2-(diethylamino-2-ethyl)9-hydroxy
ellipticinium-chloride, HCl. Cancer Res. 1987 Dec 1;47(23):6254-61. PubMed PMID:
3677074.