Datelliptium chloride
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MedKoo CAT#: 330195

CAS#: 105118-14-7 (chloride)

Description: Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. Datelliptium chloride showed anti-tumor activities.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 550 2 Weeks
100mg USD 950 2 Weeks
200mg USD 1650 2 Weeks
500mg USD 2450 2 Weeks
1g USD 3650 2 Weeks
2g USD 5450 2 Weeks
5g USD 9950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-11-23. Prices are subject to change without notice.

Datelliptium chloride, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 330195
Name: Datelliptium chloride
CAS#: 105118-14-7 (chloride)
Chemical Formula: C23H28ClN3O
Exact Mass:
Molecular Weight: 397.947
Elemental Analysis: C, 69.42; H, 7.09; Cl, 8.91; N, 10.56; O, 4.02


Related CAS #: 81531-57-9 (cation)   105118-14-7 (chloride)   81531-58-0 (acetate)   157000-76-5 (chloride HCl)   958863-79-1 (mesylate)    

Synonym: Datelliptium chloride; SR 95156A; SR95156A; SR-95156A; SR 95156; SR95156; SR-95156; NSC 311152; NSC-311152; NSC311152;

IUPAC/Chemical Name: 2-(2-(Diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido(4,3-b)carbazolium chloride

InChi Key: UCICRVXYPSKKJK-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H27N3O.ClH/c1-5-25(6-2)11-12-26-10-9-18-16(4)23-22(15(3)20(18)14-26)19-13-17(27)7-8-21(19)24-23;/h7-10,13-14,27H,5-6,11-12H2,1-4H3;1H

SMILES Code: CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Kriaa W, Sghaier-Hammami B, Masmoudi-Allouche F, Benjemaa-Masmoudi R, Drira N.
The date palm (Phoenix dactylifera L.) micropropagation using completely mature
female flowers. C R Biol. 2012 Mar;335(3):194-204. doi:
10.1016/j.crvi.2012.01.005. Epub 2012 Mar 15. PubMed PMID: 22464427.

2: Djuric Z, Everett CK, Valeriote FA. DNA damage and cytotoxicity in L1210 cells
by ellipticine and a structural analogue,
N-2-(diethylaminoethyl)-9-hydroxyellipticinium chloride. Cancer Res. 1992 Mar
15;52(6):1515-9. PubMed PMID: 1540960.

3: Khayat D, Borel C, Azab M, Paraisot D, Malaurie E, Bouloux C, Weil M. Phase I
study of Datelliptium chloride, hydrochloride given by 24-h continuous
intravenous infusion. Cancer Chemother Pharmacol. 1992;30(3):226-8. PubMed PMID:
1628372.

4: Mucci-LoRusso P, Polin L, Biernat LA, Valeriote FA, Corbett TH. Activity of
datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest
New Drugs. 1990 Aug;8(3):253-61. PubMed PMID: 2177044.

5: Multon E, Riou JF, LeFevre D, Ahomadegbe JC, Riou G. Topoisomerase II-mediated
DNA cleavage activity induced by ellipticines on the human tumor cell line N417.
Biochem Pharmacol. 1989 Jul 1;38(13):2077-86. PubMed PMID: 2544183.

6: Auclair C, Pierre A, Voisin E, Pepin O, Cros S, Colas C, Saucier JM,
Verschuere B, Gros P, Paoletti C. Physicochemical and pharmacological properties
of the antitumor ellipticine derivative 2-(diethylamino-2-ethyl)9-hydroxy
ellipticinium-chloride, HCl. Cancer Res. 1987 Dec 1;47(23):6254-61. PubMed PMID:
3677074.