Altizide, (+)-

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573706

CAS#: 133585-76-9

Description: Altizide, (+)-, is a thiazide diuretic used to treat oedema and hypertension.

Chemical Structure

Altizide, (+)-
CAS# 133585-76-9

Theoretical Analysis

MedKoo Cat#: 573706
Name: Altizide, (+)-
CAS#: 133585-76-9
Chemical Formula: C11H14ClN3O4S3
Exact Mass: 382.9835
Molecular Weight: 383.88
Elemental Analysis: C, 34.42; H, 3.68; Cl, 9.23; N, 10.95; O, 16.67; S, 25.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 5588-16-9 (racemic); 133562-97-7 ((-)- Isomer)  

Synonym: Altizide, (+)-; (+)-Altizide

IUPAC/Chemical Name: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-3-((2-propen-1-ylthio)methyl)-, 1,1-dioxide, (+)-


InChi Code: 1S/C11H14ClN3O4S3/c1-2-3-20-6-11-14-8-4-7(12)9(21(13,16)17)5-10(8)22(18,19)15-11/h2,4-5,11,14-15H,1,3,6H2,(H2,13,16,17)

SMILES Code: NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 383.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Deventer K, Pozo OJ, Van Eenoo P, Delbeke FT. Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis. J Chromatogr A. 2009 Mar 20;1216(12):2466-73. doi: 10.1016/j.chroma.2009.01.032. PubMed PMID: 19187939.

2: Degre S, Detry JM, Unger P, Cosyns J, Brohet C, Kormoss N. Effects of spironolactone-altizide on left ventricular hypertrophy. Acta Cardiol. 1998;53(5):261-7. PubMed PMID: 9922803.

3: Charneau J, Mendler M. [Acute necrotic pancreatitis and althiazide]. Gastroenterol Clin Biol. 1997;21(2):164-5. French. PubMed PMID: 9161489.

4: Poncelet P, Wehrlen M, Pelletier B, Capron MH. Spironolactone and altizide used in combination with enalapril: twenty-four-hour ambulatory recording of blood pressure. Am J Cardiol. 1990 Jun 19;65(23):33K-35K. PubMed PMID: 2191587.

5: Grünfeld JP, Wehrlen M, Pelletier B, Capron MH. Spironolactone and altizide versus converting enzyme inhibitor (enalapril). Am J Cardiol. 1990 Jun 19;65(23):28K-32K. PubMed PMID: 2191586.

6: Sternon J. Spironolactone and altizide in systemic hypertension: ambulatory multicenter study. Am J Cardiol. 1990 Jun 19;65(23):24K-27K. PubMed PMID: 1972313.

7: Dueymes JM. Clinical update: spironolactone and altizide as monotherapy in systemic hypertension. Am J Cardiol. 1990 Jun 19;65(23):20K-23K. PubMed PMID: 2191585.

8: Mngola EN. The use of a spironolactone and althiazide combination (aldactacine) in the treatment of benign essential hypertension. J Int Med Res. 1980;8(3):199-204. PubMed PMID: 6993252.

9: Deventer K, Baele G, Van Eenoo P, Pozo OJ, Delbeke FT. Stability of selected chlorinated thiazide diuretics. J Pharm Biomed Anal. 2009 Feb 20;49(2):519-24. doi: 10.1016/j.jpba.2008.11.001. PubMed PMID: 19108977.