WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565426

CAS#: 470695-03-5 (2HCl)

Description: PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.

Chemical Structure

CAS# 470695-03-5 (2HCl)

Theoretical Analysis

MedKoo Cat#: 565426
Name: PUMAi HCl
CAS#: 470695-03-5 (2HCl)
Chemical Formula: C19H28Cl2N2O3
Exact Mass: 0.00
Molecular Weight: 403.340
Elemental Analysis: C, 56.58; H, 7.00; Cl, 17.58; N, 6.95; O, 11.90

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 499985-87-4 (free base)   470695-03-5 (2HCl)   1164471-69-5 (HCl)   1352829-62-9 (R-isomer)    

Synonym: PUMAi; PUMAi HCl; PUMAi hydrochloride;

IUPAC/Chemical Name: 1-[4-(2-Hydroxyethyl)-1-piperazinyl]-3-(2-naphthyloxy)-2-propanol dihydrochloride


InChi Code: InChI=1S/C19H26N2O3.2ClH/c22-12-11-20-7-9-21(10-8-20)14-18(23)15-24-19-6-5-16-3-1-2-4-17(16)13-19;;/h1-6,13,18,22-23H,7-12,14-15H2;2*1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 403.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Leibowitz BJ, Yang L, Wei L, Buchanan ME, Rachid M, Parise RA, Beumer JH, Eiseman JL, Schoen RE, Zhang L, Yu J. Targeting p53-dependent stem cell loss for intestinal chemoprotection. Sci Transl Med. 2018 Feb 7;10(427). pii: eaam7610. doi: 10.1126/scitranslmed.aam7610. PubMed PMID: 29437148; PubMed Central PMCID: PMC5827930.

2: Mercado-Flores Y, Trejo-Aguilar A, Ramírez-Zavala B, Villa-Tanaca L, Hernández-Rodríguez C. Purification and characterization of an intracellular aspartyl acid proteinase (pumAi) from Ustilago maydis. Can J Microbiol. 2005 Feb;51(2):171-5. PubMed PMID: 16091776.

3: Mercado-Flores Y, Hernández-Rodríguez C, Ruiz-Herrera J, Villa-Tanaca L. Proteinases and exopeptidases from the phytopathogenic fungus Ustilago maydis. Mycologia. 2003 Mar-Apr;95(2):327-39. PubMed PMID: 21156619.