WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565422
Description: IC-2 is a WNT inhibitor which suppresses cell viability and WNT signaling activity, significantly reducing the CD44-positive population, and dramatically reducing the sphere-forming ability of both CD44-positive and CD44-negative HuH7 cells.
MedKoo Cat#: 565422
Chemical Formula: C33H32N4O3
Exact Mass: 532.2474
Molecular Weight: 532.64
Elemental Analysis: C, 74.41; H, 6.06; N, 10.52; O, 9.01
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: IC-2; IC 2; IC2
IUPAC/Chemical Name: (6S,9aS)-N,6-Dibenzyl-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
InChi Key: GGLYVDBOMUQXQM-XZWHSSHBSA-N
InChi Code: InChI=1S/C33H32N4O3/c38-31-18-19-36(33(40)34-21-25-12-5-2-6-13-25)30-23-35(22-27-16-9-15-26-14-7-8-17-28(26)27)32(39)29(37(30)31)20-24-10-3-1-4-11-24/h1-17,29-30H,18-23H2,(H,34,40)/t29-,30+/m0/s1
SMILES Code: O=C(N(CC1)[C@](CN(CC2=C3C=CC=CC3=CC=C2)C([C@@H]4CC5=CC=CC=C5)=O)([H])N4C1=O)NCC6=CC=CC=C6
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 532.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Itaba N, Noda I, Oka H, Kono Y, Okinaka K, Yokobata T, Okazaki S, Morimoto M, Shiota G. Hepatic cell sheets engineered from human mesenchymal stem cells with a single small molecule compound IC-2 ameliorate acute liver injury in mice. Regen Ther. 2018 Aug 24;9:45-57. doi: 10.1016/j.reth.2018.07.001. eCollection 2018 Dec. PubMed PMID: 30525075; PubMed Central PMCID: PMC6222293.
2: Wu L, He S, He Y, Wang X, Lu L. IC-2 Suppresses Proliferation and Induces Apoptosis of Bladder Cancer Cells via the Wnt/β-Catenin Pathway. Med Sci Monit. 2018 Nov 11;24:8074-8080. doi: 10.12659/MSM.910742. PubMed PMID: 30415269; PubMed Central PMCID: PMC6240849.
3: Urushibara S, Tsubota T, Asai R, Azumi J, Ashida K, Fujiwara Y, Shiota G. WNT/β-Catenin Signaling Inhibitor IC-2 Suppresses Sphere Formation and Sensitizes Colorectal Cancer Cells to 5-Fluorouracil. Anticancer Res. 2017 Aug;37(8):4085-4091. PubMed PMID: 28739692.
4: Seto K, Sakabe T, Itaba N, Azumi J, Oka H, Morimoto M, Umekita Y, Shiota G. A Novel Small-molecule WNT Inhibitor, IC-2, Has the Potential to Suppress Liver Cancer Stem Cells. Anticancer Res. 2017 Jul;37(7):3569-3579. PubMed PMID: 28668848.
5: Yokogi S, Tsubota T, Kanki K, Azumi J, Itaba N, Oka H, Morimoto M, Ryoke K, Shiota G. Wnt/Beta-Catenin Signal Inhibitor HC-1 Sensitizes Oral Squamous Cell Carcinoma Cells to 5-Fluorouracil through Reduction of CD44-Positive Population. Yonago Acta Med. 2016 Jun 29;59(2):93-9. eCollection 2016 Jun. PubMed PMID: 27493479; PubMed Central PMCID: PMC4973014.