L-778123 Dihydrochloride
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471027

CAS#: 183499-56-1 (2HCl)

Description: L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.


Chemical Structure

img
L-778123 Dihydrochloride
CAS# 183499-56-1 (2HCl)

Theoretical Analysis

MedKoo Cat#: 471027
Name: L-778123 Dihydrochloride
CAS#: 183499-56-1 (2HCl)
Chemical Formula: C22H22Cl3N5O
Exact Mass:
Molecular Weight: 478.802
Elemental Analysis: C, 55.19; H, 4.63; Cl, 22.21; N, 14.63; O, 3.34

Price and Availability

Size Price Availability Quantity
5.0mg USD 420.0 2 Weeks
Bulk inquiry

Related CAS #: 253863-00-2 (HCl)   183499-57-2 (free base)   183499-56-1 (2HCl)  

Synonym: L778123; L-778123; L 778123; L778,123; L-778,123; L 778,123 2HCl; L-778123 dihydrochloride

IUPAC/Chemical Name: 4-((5-((4-(3-chlorophenyl)-3-oxopiperazin-1-yl)methyl)-1H-imidazol-1-yl)methyl)benzonitrile dihydrochloride

InChi Key: XNGJWEBJQJQXQR-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H20ClN5O.2ClH/c23-19-2-1-3-20(10-19)28-9-8-26(15-22(28)29)14-21-12-25-16-27(21)13-18-6-4-17(11-24)5-7-18;;/h1-7,10,12,16H,8-9,13-15H2;2*1H

SMILES Code: N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2933.59.5300

Preparing Stock Solutions

The following data is based on the product molecular weight 478.802 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x