SNIPER(CRABP)-11
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MedKoo CAT#: 555560

CAS#: 1384275-50-6

Description: SNIPER(CRABP)-11, also known as PROTAC cIAP1 degrader-4, is a potent protein degrader. SNIPER(CRABP)-11 displayed degradation activity toward the mitochondrial CRABP-II protein.

Chemical Structure

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SNIPER(CRABP)-11
CAS# 1384275-50-6
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 555560
Name: SNIPER(CRABP)-11
CAS#: 1384275-50-6
Chemical Formula: C60H83N7O10
Exact Mass: 1,061.62
Molecular Weight: 1,062.360
Elemental Analysis: C, 67.84; H, 7.88; N, 9.23; O, 15.06

Price and Availability

Size Price Availability Quantity
1mg USD 190 Ready to ship
5mg USD 450 Ready to ship
10mg USD 750 Ready to ship
25mg USD 1250 Ready to ship
50mg USD 1950 Ready to ship
100mg USD 2950 Ready to ship
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Synonym: SNIPER(CRABP)-11; SNIPER(CRABP)11; SNIPER(CRABP) 11; SN-11; SN 11; SN11; PROTAC cIAP1 degrader-​4,

IUPAC/Chemical Name: (2E,4E,6E,8E)-9-((E)-3-((((S)-3-benzhydryl-1-((S)-1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidin-2-yl)-1,4,15-trioxo-8,11-dioxa-2,5,14-triazahexadecan-16-yl)oxy)imino)-2,6,6-trimethylcyclohex-1-en-1-yl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

InChi Key: JKPIDKPKBOTXBU-HMLGKSOISA-N

InChi Code: InChI=1S/C60H83N7O10/c1-41(19-17-20-42(2)39-52(69)70)28-29-48-43(3)49(30-31-60(48,5)6)66-77-40-51(68)62-32-35-75-37-38-76-36-33-63-58(73)55(53(45-21-11-8-12-22-45)46-23-13-9-14-24-46)65-57(72)50-27-18-34-67(50)59(74)54(47-25-15-10-16-26-47)64-56(71)44(4)61-7/h8-9,11-14,17,19-24,28-29,39,44,47,50,53-55,61H,10,15-16,18,25-27,30-38,40H2,1-7H3,(H,62,68)(H,63,73)(H,64,71)(H,65,72)(H,69,70)/b20-17+,29-28+,41-19+,42-39+,66-49+/t44-,50-,54-,55-/m0/s1

SMILES Code: CC(/C(CCC(C)1C)=N/OCC(NCCOCCOCCNC([C@H](C(C2=CC=CC=C2)C3=CC=CC=C3)NC([C@@H]4CCCN4C([C@H](C5CCCCC5)NC([C@H](C)NC)=O)=O)=O)=O)=O)=C1/C=C/C(C)=C/C=C/C(C)=C/C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: SNIPER(CRABP)-11 had degradation activity toward the mitochondrial CRABP-II protein.
In vitro activity: This study highlighted SNIPER molecules’ ability to target proteins in different cellular compartments. Different SNIPER(CRABP) variants were tested, but SNIPER(CRABP)-11 demonstrated degradation activity specifically for the mitochondrial CRABP-II protein. The E3 ligase responsible for degradation varied depending on the CRABP-II protein's localization. Reference: Mol Pharmacol. 2017 Mar;91(3):159-166. https://pubmed.ncbi.nlm.nih.gov/27965304/
In vivo activity: To be determined

Preparing Stock Solutions

The following data is based on the product molecular weight 1,062.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Okuhira K, Shoda T, Omura R, Ohoka N, Hattori T, Shibata N, Demizu Y, Sugihara R, Ichino A, Kawahara H, Itoh Y, Ishikawa M, Hashimoto Y, Kurihara M, Itoh S, Saito H, Naito M. Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. Mol Pharmacol. 2017 Mar;91(3):159-166. doi: 10.1124/mol.116.105569. Epub 2016 Dec 13. PMID: 27965304.
In vitro protocol: 1. Okuhira K, Shoda T, Omura R, Ohoka N, Hattori T, Shibata N, Demizu Y, Sugihara R, Ichino A, Kawahara H, Itoh Y, Ishikawa M, Hashimoto Y, Kurihara M, Itoh S, Saito H, Naito M. Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. Mol Pharmacol. 2017 Mar;91(3):159-166. doi: 10.1124/mol.116.105569. Epub 2016 Dec 13. PMID: 27965304.
In vivo protocol: To be determined

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1: Okuhira K, Shoda T, Omura R, et al. Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules. Mol Pharmacol. 2017;91(3):159–166. doi:10.1124/mol.116.105569