UCM-1336

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 408016

CAS#: 1621535-90-7

Description: UCM-1336 is a potent isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor ( IC50 = 2 μM). UCM-1336 improves survival in Ras-driven acute myeloid leukemia. UCM-1336 significantly impairs the membrane association of the four Ras isoforms, leading to a decrease of Ras activity and to inhibition of Ras downstream signaling pathways. In addition, it induces cell death in a variety of Ras-mutated tumor cell lines and increases survival in an in vivo model of acute myeloid leukemia.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-29. Prices are subject to change without notice.

UCM-1336 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 408016
Name: UCM-1336
CAS#: 1621535-90-7
Chemical Formula: C26H37N3O2
Exact Mass: 423.2886
Molecular Weight: 423.6
Elemental Analysis: C, 73.72; H, 8.80; N, 9.92; O, 7.55


Synonym: UCM-1336; UCM 1336; UCM1336;

IUPAC/Chemical Name: 3,3'-(octylazanediyl)bis(N-phenylpropanamide)

InChi Key: RHEOHKVMYINBGT-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H37N3O2/c1-2-3-4-5-6-13-20-29(21-18-25(30)27-23-14-9-7-10-15-23)22-19-26(31)28-24-16-11-8-12-17-24/h7-12,14-17H,2-6,13,18-22H2,1H3,(H,27,30)(H,28,31)

SMILES Code: O=C(NC1=CC=CC=C1)CCN(CCC(NC2=CC=CC=C2)=O)CCCCCCCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001