Alitame

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573674

CAS#: 99016-42-9

Description: Alitame is a non-nutritive sweetener that is 2000 times sweeter than sucrose. It is formed from aspartic acid, alanine & an amide.


Chemical Structure

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Alitame
CAS# 99016-42-9

Theoretical Analysis

MedKoo Cat#: 573674
Name: Alitame
CAS#: 99016-42-9
Chemical Formula: C28H60N6O13S2
Exact Mass: 752.37
Molecular Weight: 752.940
Elemental Analysis: C, 44.67; H, 8.03; N, 11.16; O, 27.62; S, 8.52

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Alitame, CP 54802, CP-54,802; HSDB 7825

IUPAC/Chemical Name: bis(N4-((R)-1-oxo-1-((2,2,4,4-tetramethylthietan-3-yl)amino)propan-2-yl)-D-asparagine) pentahydrate

InChi Key: NUFKRGBSZPCGQB-FLBSXDLDSA-N

InChi Code: 1S/2C14H25N3O4S.5H2O/c2*1-7(16-11(21)8(15)6-9(18)19)10(20)17-12-13(2,3)22-14(12,4)5;;;;;/h2*7-8,12H,6,15H2,1-5H3,(H,16,21)(H,17,20)(H,18,19);5*1H2/t2*7-,8+;;;;;/m11...../s1

SMILES Code: O.O.O.O.O.C[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NC1C(C)(C)SC1(C)C.C[C@@H](NC(=O)[C@@H](N)CC(=O)O)C(=O)NC2C(C)(C)SC2(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 752.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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6: Jiang D, Fang C, Yang D. [Simultaneous determination of aspartame and alitame in jellies and preserved fruits by HPLC]. Wei Sheng Yan Jiu. 2012 May;41(3):467-70, 475. Chinese. PubMed PMID: 23050451.

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9: Liu X, Ding L, Liu J, Zhang Y, Huang Z, Wang L, Chen B. [Simultaneous determination of six synthetic sweeteners in food by high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2010 Nov;28(11):1020-5. Chinese. PubMed PMID: 21381416.

10: Zygler A, Wasik A, Namieśnik J. Retention behaviour of some high-intensity sweeteners on different SPE sorbents. Talanta. 2010 Oct 15;82(5):1742-8. doi: 10.1016/j.talanta.2010.07.070. Epub 2010 Aug 6. PubMed PMID: 20875571.

11: Hellekant G, Roberts T, Elmer D, Cragin T, Danilova V. Responses of single chorda tympani taste fibers of the calf (Bos taurus). Chem Senses. 2010 Jun;35(5):383-94. doi: 10.1093/chemse/bjq026. Epub 2010 Mar 8. PubMed PMID: 20212013; PubMed Central PMCID: PMC2871778.

12: Buchgraber M, Wasik A. Determination of nine intense sweeteners in foodstuffs by high-performance liquid chromatography and evaporative light-scattering detection: interlaboratory study. J AOAC Int. 2009 Jan-Feb;92(1):208-22. PubMed PMID: 19382579.

13: Yang DJ, Chen B. Simultaneous determination of nonnutritive sweeteners in foods by HPLC/ESI-MS. J Agric Food Chem. 2009 Apr 22;57(8):3022-7. doi: 10.1021/jf803988u. PubMed PMID: 19275236.

14: Assadi-Porter FM, Tonelli M, Maillet E, Hallenga K, Benard O, Max M, Markley JL. Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR. J Am Chem Soc. 2008 Jun 11;130(23):7212-3. doi: 10.1021/ja8016939. Epub 2008 May 16. PubMed PMID: 18481853; PubMed Central PMCID: PMC2759897.

15: Matsumoto H, Hirata K, Sakamaki N, Hagino K, Ushiyama H. [Simultaneous determination of neotame, alitame and aspartame in foods by HPLC]. Shokuhin Eiseigaku Zasshi. 2008 Feb;49(1):31-6. Japanese. PubMed PMID: 18344656.

16: Wasik A, McCourt J, Buchgraber M. Simultaneous determination of nine intense sweeteners in foodstuffs by high performance liquid chromatography and evaporative light scattering detection--development and single-laboratory validation. J Chromatogr A. 2007 Jul 20;1157(1-2):187-96. Epub 2007 May 6. PubMed PMID: 17540386.

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18: Weihrauch MR, Diehl V. Artificial sweeteners--do they bear a carcinogenic risk? Ann Oncol. 2004 Oct;15(10):1460-5. Review. PubMed PMID: 15367404.

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