WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 408015
CAS#: 2284621-75-4
Description: MUN21754, also known as JAK/HDAC-IN-1, is a potent and selective dual JAK2/HDAC inhibitor, MUN21754 exhibits antiproliferative and proapoptotic activities in several hematological cell lines. MUN21754 has CAS#2284621-75-4 and inchi key MTOQNLGMTJOJOF-UHFFFAOYSA-N. This product has no formal name. For the convenience of communication, we name it MUN21754. The 3 letters from its inch key and last 5 digit CAS# was used for name.
MedKoo Cat#: 408015
Name: MUN21754
CAS#: 2284621-75-4
Chemical Formula: C19H21Cl2N7O2
Exact Mass: 449.1134
Molecular Weight: 450.324
Elemental Analysis: C, 50.68; H, 4.70; Cl, 15.74; N, 21.77; O, 7.11
Synonym: JAK/HDAC-IN-1; MUN21754; MUN-21754; MUN 21754;
IUPAC/Chemical Name: 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexanamide
InChi Key: MTOQNLGMTJOJOF-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)
SMILES Code: O=C(NO)CCCCCN1N=CC(NC2=NC=C(Cl)C(NC3=CC=C(Cl)C=C3)=N2)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 450.324 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.
