MUN21754
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MedKoo CAT#: 408015

CAS#: 2284621-75-4

Description: MUN21754, also known as JAK/HDAC-IN-1, is a potent and selective dual JAK2/HDAC inhibitor, MUN21754 exhibits antiproliferative and proapoptotic activities in several hematological cell lines. MUN21754 has CAS#2284621-75-4 and inchi key MTOQNLGMTJOJOF-UHFFFAOYSA-N. This product has no formal name. For the convenience of communication, we name it MUN21754. The 3 letters from its inch key and last 5 digit CAS# was used for name.


Chemical Structure

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MUN21754
CAS# 2284621-75-4

Theoretical Analysis

MedKoo Cat#: 408015
Name: MUN21754
CAS#: 2284621-75-4
Chemical Formula: C19H21Cl2N7O2
Exact Mass: 449.1134
Molecular Weight: 450.324
Elemental Analysis: C, 50.68; H, 4.70; Cl, 15.74; N, 21.77; O, 7.11

Price and Availability

Size Price Availability Quantity
1.0g USD 4250.0 2 Weeks
2.0g USD 7450.0 2 Weeks
5.0g USD 14650.0 2 Weeks
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Synonym: JAK/HDAC-IN-1; MUN21754; MUN-21754; MUN 21754;

IUPAC/Chemical Name: 6-(4-((5-chloro-4-((4-chlorophenyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)-N-hydroxyhexanamide

InChi Key: MTOQNLGMTJOJOF-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21Cl2N7O2/c20-13-5-7-14(8-6-13)24-18-16(21)11-22-19(26-18)25-15-10-23-28(12-15)9-3-1-2-4-17(29)27-30/h5-8,10-12,30H,1-4,9H2,(H,27,29)(H2,22,24,25,26)

SMILES Code: O=C(NO)CCCCCN1N=CC(NC2=NC=C(Cl)C(NC3=CC=C(Cl)C=C3)=N2)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 450.324 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.