WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584969
Description: P-1946 is an HIV-1 protease inhibitor.
MedKoo Cat#: 584969
Chemical Formula: C29H41N5O6S
Exact Mass: 587.2778
Molecular Weight: 587.736
Elemental Analysis: C, 59.26; H, 7.03; N, 11.92; O, 16.33; S, 5.45
This product is not in stock, which may be available by custom synthesis.
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Synonym: P-1946; P1946; P 1946
IUPAC/Chemical Name: Carbamic acid, ((1S)-2-(((5S)-5-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-6-hydroxyhexyl)amino)-1-(1H-indol-3-ylmethyl)-2-oxoethyl)-, methyl ester
InChi Key: KLFMLSLUVACAEA-HOFKKMOUSA-N
InChi Code: InChI=1S/C29H41N5O6S/c1-20(2)18-34(41(38,39)24-13-11-22(30)12-14-24)23(19-35)8-6-7-15-31-28(36)27(33-29(37)40-3)16-21-17-32-26-10-5-4-9-25(21)26/h4-5,9-14,17,20,23,27,32,35H,6-8,15-16,18-19,30H2,1-3H3,(H,31,36)(H,33,37)/t23-,27-/m0/s1
SMILES Code: O=C(OC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCCCC[C@H](N(S(=O)(C3=CC=C(N)C=C3)=O)CC(C)C)CO)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 587.736 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Sévigny G, Stranix B, Tian B, Dubois A, Sauvé G, Petropoulos C, Lie Y, Hellmann N, Conway B, Yelle J. Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor. Antiviral Res. 2006 Jun;70(2):17-20. Epub 2006 Jan 20. PubMed PMID: 16473417.
2: Corrections and clarifications. Science. 1993 Feb 5;259(5096):747. PubMed PMID: 17809322.
3: Benedetti S, Casamenti V, Benedetti M. Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia: five-year study. J Cataract Refract Surg. 2007 May;33(5):784-90. PubMed PMID: 17466848.