WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565351
Description: Osteosarcoma-IN-D15 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes.
MedKoo Cat#: 565351
Chemical Formula: C20H17NO
Exact Mass: 287.131
Molecular Weight: 287.36
Elemental Analysis: C, 83.59; H, 5.96; N, 4.87; O, 5.57
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Synonym: Osteosarcoma IN-D15; Osteosarcoma-IN D15; Osteosarcoma-IN-D15
IUPAC/Chemical Name: (E)-1-(4-aminophenyl)-3-(4-methylnaphthalen-1-yl)prop-2-en-1-one
InChi Key: OJOYQEDRRZUUMP-JLHYYAGUSA-N
InChi Code: InChI=1S/C20H17NO/c1-14-6-7-15(19-5-3-2-4-18(14)19)10-13-20(22)16-8-11-17(21)12-9-16/h2-13H,21H2,1H3/b13-10+
SMILES Code: NC1=CC=C(C(/C=C/C2=CC=C(C)C3=C2C=CC=C3)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 287.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Seba V, Silva G, Santos MBD, Baek SJ, França SC, Fachin AL, Regasini LO, Marins M. Chalcone Derivatives 4'-Amino-1-Naphthyl-Chalcone (D14) and 4'-Amino-4-Methyl-1-Naphthyl-Chalcone (D15) Suppress Migration and Invasion of Osteosarcoma Cells Mediated by p53 Regulating EMT-Related Genes. Int J Mol Sci. 2018 Sep 19;19(9). pii: E2838. doi: 10.3390/ijms19092838. PubMed PMID: 30235848; PubMed Central PMCID: PMC6163733.