EAI001

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 408011

CAS#: 892772-75-7

Description: EAI001 was the first non-ATP competitive EGFRL858R/T790M/C797S inhibitor.


Chemical Structure

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EAI001
CAS# 892772-75-7

Theoretical Analysis

MedKoo Cat#: 408011
Name: EAI001
CAS#: 892772-75-7
Chemical Formula: C19H15N3O2S
Exact Mass: 349.09
Molecular Weight: 349.408
Elemental Analysis: C, 65.31; H, 4.33; N, 12.03; O, 9.16; S, 9.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: EAI001; EAI-001; EAI 001;

IUPAC/Chemical Name: 2-(1-oxoisoindolin-2-yl)-2-phenyl-N-(thiazol-2-yl)acetamide

InChi Key: PWRVRDCBFYLYFU-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H15N3O2S/c23-17(21-19-20-10-11-25-19)16(13-6-2-1-3-7-13)22-12-14-8-4-5-9-15(14)18(22)24/h1-11,16H,12H2,(H,20,21,23)

SMILES Code: O=C(NC1=NC=CS1)C(N(CC2=C3C=CC=C2)C3=O)C4=CC=CC=C4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wan S, Yan R, Jiang Y, Li Z, Wu X. Insight into Binding Mechanisms of EGFR
Allosteric Inhibitors using Molecular Dynamics Simulations and Free Energy
Calculations. J Biomol Struct Dyn. 2018 Nov 30:1-20. doi:
10.1080/07391102.2018.1552197. [Epub ahead of print] PubMed PMID: 30499387.


2: Zhao P, Yao MY, Zhu SJ, Chen JY, Yun CH. Crystal structure of EGFR
T790M/C797S/V948R in complex with EAI045. Biochem Biophys Res Commun. 2018 Jul
20;502(3):332-337. doi: 10.1016/j.bbrc.2018.05.154. PubMed PMID: 29802850.