VU 0650991
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584952

CAS#: 488097-06-9

Description: VU 0650991 is a non-competitive GLP-1 antagonist that is orally bioavailable and acts as a brain penetrant.

Chemical Structure

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VU 0650991
CAS# 488097-06-9
Instruction

Theoretical Analysis

MedKoo Cat#: 584952
Name: VU 0650991
CAS#: 488097-06-9
Chemical Formula: C16H11ClF6N4O2
Exact Mass: 440.05
Molecular Weight: 440.730
Elemental Analysis: C, 43.60; H, 2.52; Cl, 8.04; F, 25.86; N, 12.71; O, 7.26

Price and Availability

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10mg USD 400
50mg USD 1200
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Synonym: VU 0650991; VU0650991; VU-0650991

IUPAC/Chemical Name: 7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

InChi Key: MFEIZMHODFOWAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H11ClF6N4O2/c1-26-11-9(12(28)27(2)13(26)29)14(15(18,19)20,16(21,22)23)25-10(24-11)7-3-5-8(17)6-4-7/h3-6H,1-2H3,(H,24,25)

SMILES Code: O=C1N(C)C(NC(C2=CC=C(Cl)C=C2)=NC3(C(F)(F)F)C(F)(F)F)=C3C(N1C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Nance et al (2017) Discovery of a novel series of orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) noncompetitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H J.Med.Chem. 60 1611 PMID: 28103022