Norspermine
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MedKoo CAT#: 573618

CAS#: 4605-14-5

Description: Norspermine is a polyamine analogue which may be useful in the treatment of non-small cell lung carcinoma and breast cancer.

Chemical Structure

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Norspermine
CAS# 4605-14-5
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 573618
Name: Norspermine
CAS#: 4605-14-5
Chemical Formula: C9H24N4
Exact Mass: 188.20
Molecular Weight: 188.319
Elemental Analysis: C, 57.40; H, 12.85; N, 29.75

Price and Availability

Size Price Availability Quantity
1g USD 350 2 Weeks
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Synonym: AI3-61617, Norspermine, Norspermidine

IUPAC/Chemical Name: 1,3-Propanediamine, N,N'-bis(3-aminopropyl)-

InChi Key: ZAXCZCOUDLENMH-UHFFFAOYSA-N

InChi Code: 1S/C9H24N4/c10-4-1-6-12-8-3-9-13-7-2-5-11/h12-13H,1-11H2

SMILES Code: N(CCCNCCCN)CCCN

Appearance: liquid

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Certificate of Analysis:
View CoA: current batch, Lot#C23B05B16
Safety Data Sheet (SDS):
View Safety Data Sheet (SDS)
Instruction:
View handling instruction
Biological target: Norspermine is a polyamine analogue which may be useful in the treatment of non-small cell lung carcinoma and breast cancer.
In vitro activity: TBD
In vivo activity: TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 188.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: TBD
In vitro protocol: TBD
In vivo protocol: TBD

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1: Nair SK, Verma A, Thomas TJ, Chou TC, Gallo MA, Shirahata A, Thomas T. Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer Lett. 2007 Jun 8;250(2):311-22. Epub 2006 Dec 20. PubMed PMID: 17184909; PubMed Central PMCID: PMC1899838.

2: Gabrielson EW, Pegg AE, Casero RA Jr. The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Clin Cancer Res. 1999 Jul;5(7):1638-41. PubMed PMID: 10430062.

3: Porter CW, Bernacki RJ, Miller J, Bergeron RJ. Antitumor activity of N1,N11-bis(ethyl)norspermine against human melanoma xenografts and possible biochemical correlates of drug action. Cancer Res. 1993 Feb 1;53(3):581-6. PubMed PMID: 8425191.