Camptothecin sodium
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MedKoo CAT#: 573615

CAS#: 25387-67-1

Description: Camptothecin sodium selectively inhibits the nuclear enzyme DNA Topoisomerase, Type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.


Chemical Structure

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Camptothecin sodium
CAS# 25387-67-1

Theoretical Analysis

MedKoo Cat#: 573615
Name: Camptothecin sodium
CAS#: 25387-67-1
Chemical Formula: C20H17N2NaO5
Exact Mass: 388.1035
Molecular Weight: 388.35
Elemental Analysis: C, 61.86; H, 4.41; N, 7.21; Na, 5.92; O, 20.60

Price and Availability

Size Price Availability Quantity
1.0g USD 900.0 2 Weeks
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Synonym: 20(S)-Camptothecin sodium salt, AI3-62931, Camptothecine sodium, Camptothecin, sodium salt, Camptothecin sodium, NSC-100880, Sodium camptothecin

IUPAC/Chemical Name: Indolizino(1,2-b)quinoline-7-acetic acid, alpha-ethyl-9,11-dihydro-alpha-hydroxy-8-(hydroxymethyl)-9-oxo-, monosodium salt, (S)- (9CI)

InChi Key: HVGXXVCXEMRSLD-BDQAORGHSA-N

InChi Code: 1S/C20H15N2O4.Na/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24;/h3-8H,2,9-10H2,1H3;/q-1;+1/t20-;/m0./s1

SMILES Code: CC[C@@]1(c2cc-3n(c(=O)c2COC1=O)Cc4c3nc5ccccc5c4)[O-].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 388.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Ibrahim S, Gao D, Sinko PJ. Selective cytotoxicity and combined effects of camptothecin or paclitaxel with sodium-R-alpha lipoate on A549 human non-small cell lung cancer cells. Nutr Cancer. 2014;66(3):492-9. doi: 10.1080/01635581.2013.749290. Epub 2013 Sep 24. PubMed PMID: 24063429; PubMed Central PMCID: PMC3964140.

2: Lauricella M, Calvaruso G, Giuliano M, Carabillò M, Emanuele S, Vento R, Tesoriere G. Synergistic cytotoxic interactions between sodium butyrate, MG132 and camptothecin in human retinoblastoma Y79 cells. Tumour Biol. 2000 Nov-Dec;21(6):337-48. PubMed PMID: 11006574.