AFD-R

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565294

CAS#: NONE

Description: AFD-R is a potent immunomodulator which activates sphingosine-1-phosphate receptor. AFD-R is a prodrug of ALL-R, and a derivative of FTY720.

Chemical Structure

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AFD-R
CAS# NONE
Instruction

Theoretical Analysis

MedKoo Cat#: 565294
Name: AFD-R
CAS#: NONE
Chemical Formula: C18H30NNa2O5P
Exact Mass: 0.00
Molecular Weight: 417.390
Elemental Analysis: C, 51.80; H, 7.24; N, 3.36; Na, 11.02; O, 19.17; P, 7.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AFD R; AFD R; AFD-R; AFD-(R); AFD (R); AFD(R)

IUPAC/Chemical Name: (R)-2-Amino-4-(4-heptyloxyphenyl)-2-methylbutyl phosphate disodium salt

InChi Key: JRYPJBDCVMPUHH-JPKZNVRTSA-L

InChi Code: InChI=1S/C18H32NO5P.2Na/c1-3-4-5-6-7-14-23-17-10-8-16(9-11-17)12-13-18(2,19)15-24-25(20,21)22;;/h8-11H,3-7,12-15,19H2,1-2H3,(H2,20,21,22);;/q;2*+1/p-2/t18-;;/m1../s1

SMILES Code: O=P([O-])([O-])OC[C@](C)(N)CCC1=CC=C(OCCCCCCC)C=C1.[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 417.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gendron DR, Lecours PB, Lemay AM, Beaulieu MJ, Huppé CA, Lee-Gosselin A, Flamand N, Don AS, Bissonnette É, Blanchet MR, Laplante M, Bourgoin SG, Bossé Y, Marsolais D. A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma. Front Pharmacol. 2017 Feb 21;8:78. doi: 10.3389/fphar.2017.00078. eCollection 2017. PubMed PMID: 28270767; PubMed Central PMCID: PMC5318459.

2: Gendron D, Lemay AM, Tremblay C, Lai LJ, Langlois A, Bernatchez É, Flamand N, Blanchet MR, Don AS, Bossé Y, Bissonnette É, Marsolais D. Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma. Respir Res. 2015 Feb 3;16:7. doi: 10.1186/s12931-015-0180-z. PubMed PMID: 25645346; PubMed Central PMCID: PMC4330646.

3: Don AS, Martinez-Lamenca C, Webb WR, Proia RL, Roberts E, Rosen H. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J Biol Chem. 2007 May 25;282(21):15833-42. Epub 2007 Mar 30. PubMed PMID: 17400555.

4: Gonzalez-Cabrera PJ, Hla T, Rosen H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. J Biol Chem. 2007 Mar 9;282(10):7254-64. Epub 2007 Jan 10. PubMed PMID: 17218309.