KKL-35 | CAS#865285-29-6 | TT inhibitor

KKL-35
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555536

CAS#: 865285-29-6

Description: KKL-35 is a potent trans-translation inhibitor that has broad-spectrum antibiotic activity. KKL-35 Exhibits Potent Antibiotic Activity against Legionella Species Independently of trans-Translation Inhibition. KKL-35 inhibited the growth of all tested strains at submicromolar concentrations. KKL-35 was also active against other LD-causing Legionella species. KKL-35 remained equally active against L. pneumophila mutants that have evolved resistance to macrolides. KKL-35 inhibited the multiplication of L. pneumophila in human macrophages at several stages of infection.

Chemical Structure

KKL-35

CAS# 865285-29-6

Instruction

Theoretical Analysis

MedKoo Cat#: 555536
Name: KKL-35
CAS#: 865285-29-6
Chemical Formula: C11H12ClN5O
Exact Mass: 265.07
Molecular Weight: 265.701
Elemental Analysis: C, 49.73; H, 4.55; Cl, 13.34; N, 26.36; O, 6.02

Price and Availability

Size	Price	Availability
50mg	USD 450	2 Weeks
100mg	USD 750	2 Weeks
200mg	USD 1250	2 Weeks
500mg	USD 2650	2 Weeks
1g	USD 3850	2 Weeks
2g	USD 5950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: KKL-35; KKL 35; KKL35;

IUPAC/Chemical Name: 3-chloro-N-(1-propyl-1H-tetrazol-5-yl)benzamide

InChi Key: IBRCUOMIAFDQTM-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H12ClN5O/c1-2-6-17-11(14-15-16-17)13-10(18)8-4-3-5-9(12)7-8/h3-5,7H,2,6H2,1H3,(H,13,14,16,18)

SMILES Code: O=C(NC1=NN=NN1CCC)C2=CC=CC(Cl)=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: trans-Translation is a ribosome-rescue system that is ubiquitous in bacteria. Small molecules defining a new family of oxadiazole compounds that inhibit trans-translation have been found to have broad-spectrum antibiotic activity.

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 265.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Brunel R, Descours G, Durieux I, Doublet P, Jarraud S, Charpentier X. KKL-35
Exhibits Potent Antibiotic Activity against Legionella Species Independently of
trans-Translation Inhibition. Antimicrob Agents Chemother. 2018 Jan 25;62(2).
pii: e01459-17. doi: 10.1128/AAC.01459-17. Print 2018 Feb. PubMed PMID: 29158279;
PubMed Central PMCID: PMC5786812.

2: Macé K, Demay F, Guyomar C, Georgeault S, Giudice E, Goude R, Trautwetter A,
Ermel G, Blanco C, Gillet R. A Genetic Tool to Quantify trans-Translation
Activity in Vivo. J Mol Biol. 2017 Nov 24;429(23):3617-3625. doi:
10.1016/j.jmb.2017.10.007. Epub 2017 Oct 13. PubMed PMID: 29031699.

3: Alumasa JN, Manzanillo PS, Peterson ND, Lundrigan T, Baughn AD, Cox JS, Keiler
KC. Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister
Mycobacterium tuberculosis Cells. ACS Infect Dis. 2017 Sep 8;3(9):634-644. doi:
10.1021/acsinfecdis.7b00028. Epub 2017 Aug 7. PubMed PMID: 28762275; PubMed
Central PMCID: PMC5594445.

4: Ramadoss NS, Alumasa JN, Cheng L, Wang Y, Li S, Chambers BS, Chang H,
Chatterjee AK, Brinker A, Engels IH, Keiler KC. Small molecule inhibitors of
trans-translation have broad-spectrum antibiotic activity. Proc Natl Acad Sci U S
A. 2013 Jun 18;110(25):10282-7. doi: 10.1073/pnas.1302816110. Epub 2013 Jun 3.
PubMed PMID: 23733947; PubMed Central PMCID: PMC3690859.

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KKL-35 featured