WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 408005
CAS#: 681282-09-7 (free base)
Description: MYCMI-6, also known as NSC354961, is a selective, high affinity inhibitor of MYC-MAX interaction. MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity ligation, microscale thermophoresis and surface plasmon resonance (SPR) assays. Further, MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a KD of 1.6 ± 0.5 μM as demonstrated by SPR.
MedKoo Cat#: 408005
CAS#: 681282-09-7 (free base)
Chemical Formula: C20H19N7O
Exact Mass: 373.1651
Molecular Weight: 373.42
Elemental Analysis: C, 64.33; H, 5.13; N, 26.26; O, 4.28
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Related CAS #: 1093100-07-2 (2HCl) 681282-09-7 (free base)
Synonym: MYCMI-6; MYCMI-6; MYCMI-6; NSC354961; NSC-354961; NSC 354961; BXI 61; BXI-61; BXI61;
IUPAC/Chemical Name: (E)-3-((9-amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine
InChi Key: QNWGRUNKGVWOTA-CYYJNZCTSA-N
InChi Code: InChI=1S/C20H19N7O/c1-2-28-12-4-6-15-14(10-12)19(22)13-5-3-11(9-17(13)24-15)26-27-16-7-8-18(21)25-20(16)23/h3-10H,2H2,1H3,(H2,22,24)(H4,21,23,25)/b27-26+
SMILES Code: NC1=NC(N)=CC=C1/N=N/C2=CC3=NC4=CC=C(OCC)C=C4C(N)=C3C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 373.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Castell A, Yan Q, Fawkner K, Hydbring P, Zhang F, Verschut V, Franco M,
Zakaria SM, Bazzar W, Goodwin J, Zinzalla G, Larsson LG. A selective high
affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent
tumor cell proliferation. Sci Rep. 2018 Jul 3;8(1):10064. doi:
10.1038/s41598-018-28107-4. PubMed PMID: 29968736; PubMed Central PMCID:
MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 concentrations as low as 0.5 μM, while sparing normal cells. The response to MYCMI-6 correlates with MYC expression based on data from 60 human tumor cell lines and is abrogated by MYC depletion. Further, it inhibits MYC:MAX interaction, reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects. Since MYCMI-6 does not affect MYC expression, it is a unique molecular tool to specifically target MYC:MAX pharmacologically and it has good potential for drug development.