MYCMI-6

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MedKoo CAT#: 408005

CAS#: 681282-09-7 (free base)

Description: MYCMI-6, also known as NSC354961, is a selective, high affinity inhibitor of MYC-MAX interaction. MYCMI-6 exhibits strong selective inhibition of MYC:MAX interaction in cells and in vitro at single-digit micromolar concentrations, as validated by split Gaussia luciferase, in situ proximity ligation, microscale thermophoresis and surface plasmon resonance (SPR) assays. Further, MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a KD of 1.6 ± 0.5 μM as demonstrated by SPR.


Chemical Structure

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MYCMI-6
CAS# 681282-09-7 (free base)

Theoretical Analysis

MedKoo Cat#: 408005
Name: MYCMI-6
CAS#: 681282-09-7 (free base)
Chemical Formula: C20H19N7O
Exact Mass: 373.1651
Molecular Weight: 373.42
Elemental Analysis: C, 64.33; H, 5.13; N, 26.26; O, 4.28

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
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Related CAS #: 1093100-07-2 (2HCl)   681282-09-7 (free base)    

Synonym: MYCMI-6; MYCMI-6; MYCMI-6; NSC354961; NSC-354961; NSC 354961; BXI 61; BXI-61; BXI61;

IUPAC/Chemical Name: (E)-3-((9-amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine

InChi Key: QNWGRUNKGVWOTA-CYYJNZCTSA-N

InChi Code: InChI=1S/C20H19N7O/c1-2-28-12-4-6-15-14(10-12)19(22)13-5-3-11(9-17(13)24-15)26-27-16-7-8-18(21)25-20(16)23/h3-10H,2H2,1H3,(H2,22,24)(H4,21,23,25)/b27-26+

SMILES Code: NC1=NC(N)=CC=C1/N=N/C2=CC3=NC4=CC=C(OCC)C=C4C(N)=C3C=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 373.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Castell A, Yan Q, Fawkner K, Hydbring P, Zhang F, Verschut V, Franco M,
Zakaria SM, Bazzar W, Goodwin J, Zinzalla G, Larsson LG. A selective high
affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent
tumor cell proliferation. Sci Rep. 2018 Jul 3;8(1):10064. doi:
10.1038/s41598-018-28107-4. PubMed PMID: 29968736; PubMed Central PMCID:
PMC6030159.



Additional Information

MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner with IC50 concentrations as low as 0.5 μM, while sparing normal cells. The response to MYCMI-6 correlates with MYC expression based on data from 60 human tumor cell lines and is abrogated by MYC depletion. Further, it inhibits MYC:MAX interaction, reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects. Since MYCMI-6 does not affect MYC expression, it is a unique molecular tool to specifically target MYC:MAX pharmacologically and it has good potential for drug development.