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GNE-477
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471024

CAS#: 1032754-81-6

Description: GNE-477 is a dual inhibitor of PI3K (IC50 = 4 nM for PI3Kα) and mTOR (apparent Ki = 21 nM).


Price and Availability

Size Price Shipping out time Quantity
5mg USD 300 2 Weeks
10mg USD 500 2 Weeks
Inquire bulk and customized quantity
Pricing updated 2020-10-22. Prices are subject to change without notice.

GNE-477, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 471024
Name: GNE-477
CAS#: 1032754-81-6
Chemical Formula: C21H28N8O3S2
Exact Mass: 504.1726
Molecular Weight: 504.628
Elemental Analysis: C, 49.98; H, 5.59; N, 22.21; O, 9.51; S, 12.71


Synonym: GNE-477, GNE477, GNE 477

IUPAC/Chemical Name: 5-(7-methyl-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)pyrimidin-2-amine

InChi Key: AKKCGLXULFRAET-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H28N8O3S2/c1-14-16(13-27-3-5-29(6-4-27)34(2,30)31)33-18-17(14)25-19(15-11-23-21(22)24-12-15)26-20(18)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)

SMILES Code: NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(CN5CCN(S(=O)(C)=O)CC5)S4)=N2)C=N1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1. Heffron, T.P., Berry, M., Castanedo, G., et al. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor Bioorg. Med. Chem. Lett. 20(8), 2408-2411 (2010).