Orazamide

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573591

CAS#: 2574-78-9

Description: Orazamide is a therapeutic drug that may be useful in the treatment of chronic hepatitis and various skin diseases.

Chemical Structure

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Orazamide
CAS# 2574-78-9
Instruction

Theoretical Analysis

MedKoo Cat#: 573591
Name: Orazamide
CAS#: 2574-78-9
Chemical Formula: C9H14N6O7
Exact Mass: 318.09
Molecular Weight: 318.250
Elemental Analysis: C, 33.97; H, 4.43; N, 26.41; O, 35.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Aica orotate dihydrate, Aicamin dihydrate, Aicorat dihydrate, Orazamide, Orazamide dihydrate

IUPAC/Chemical Name: 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid, compoundwith 5-amino-1H-imidazole-4-carboxamide (1:1) dihydrate

InChi Key: PVCSUEOGEIOUHG-UHFFFAOYSA-N

InChi Code: 1S/C5H4N2O4.C4H6N4O/c8-3-1-2(4(9)10)6-5(11)7-3;5-3-2(4(6)9)7-1-8-3/h1H,(H,9,10)(H2,6,7,8,11);1H,5H2,(H2,6,9)(H,7,8)

SMILES Code: NC(=O)c1nc[nH]c1N.OC(=O)C2=CC(=O)NC(=O)N2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 318.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Chen X, Jing J, Ren W, Han DE, Jing N, Wang G. Determination of 5-aminoimidazole-4-carboxamide in human plasma by ion-pair extraction and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):140-4. Epub 2007 May 10. PubMed PMID: 17561451.

2: Pár A, Paál M, Kádas I, Nagy I, Kerekes E, Jávor T. Experiences with Catergen treatment in chronic active hepatitis. Ther Hung. 1983;31(3):105-14. PubMed PMID: 6400472.

3: Roda E, Sama C, Festi D. [Controlled clinical evaluation of the therapeutic effectiveness of AICA orotate in chronic hepatitis]. Clin Ter. 1979 Jun 15;89(5):489-93. Italian. PubMed PMID: 535326.

4: MIYAZAWA T, KUMASAKA S. [THE PHARMACOLOGICAL ACTIVITY OF AICA OROTATE IN VARIOUS SKIN DISEASES]. Hifuka Kiyo. 1965 Feb;60:76-84. Japanese. PubMed PMID: 14286713.