Orf 12592

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584938

CAS#: 81907-79-1

Description: Orf 12592 is a 5-hydroxy analog of propranolol that possesses antihypertensive and beta-blocking properties in anesthetized dog.

Chemical Structure

Orf 12592
CAS# 81907-79-1

Theoretical Analysis

MedKoo Cat#: 584938
Name: Orf 12592
CAS#: 81907-79-1
Chemical Formula: C16H21NO3
Exact Mass: 275.1521
Molecular Weight: 275.348
Elemental Analysis: C, 69.79; H, 7.69; N, 5.09; O, 17.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Orf 12592; Orf12592; Orf-12592

IUPAC/Chemical Name: 1-Naphthalenol, 5-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-


InChi Code: InChI=1S/C16H21NO3/c1-11(2)17-9-12(18)10-20-16-8-4-5-13-14(16)6-3-7-15(13)19/h3-8,11-12,17-19H,9-10H2,1-2H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 275.348 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Greenslade FC, Newquist KL. In vitro measurement of the beta-adrenergic blocking properties of ORF 12592, the 5-hydroxy analog of propranolol. Arch Int Pharmacodyn Ther. 1978 Jun;233(2):270-80. PubMed PMID: 28704.

2: Ram N, Bauer EW, Hesse UC, Heilman RD. Cardiovascular effects of 5-hydroxypropranolol (ORF 12592) in dogs. Arch Int Pharmacodyn Ther. 1977 Jul;228(1):118-25. PubMed PMID: 921395.