WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584938
CAS#: 81907-79-1
Description: Orf 12592 is a 5-hydroxy analog of propranolol that possesses antihypertensive and beta-blocking properties in anesthetized dog.
MedKoo Cat#: 584938
Name: Orf 12592
CAS#: 81907-79-1
Chemical Formula: C16H21NO3
Exact Mass: 275.1521
Molecular Weight: 275.348
Elemental Analysis: C, 69.79; H, 7.69; N, 5.09; O, 17.43
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Synonym: Orf 12592; Orf12592; Orf-12592
IUPAC/Chemical Name: 1-Naphthalenol, 5-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-
InChi Key: WMYPGILKDMWISO-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H21NO3/c1-11(2)17-9-12(18)10-20-16-8-4-5-13-14(16)6-3-7-15(13)19/h3-8,11-12,17-19H,9-10H2,1-2H3
SMILES Code: OC1=C2C=CC=C(OCC(O)CNC(C)C)C2=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 275.348 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Greenslade FC, Newquist KL. In vitro measurement of the beta-adrenergic blocking properties of ORF 12592, the 5-hydroxy analog of propranolol. Arch Int Pharmacodyn Ther. 1978 Jun;233(2):270-80. PubMed PMID: 28704.
2: Ram N, Bauer EW, Hesse UC, Heilman RD. Cardiovascular effects of 5-hydroxypropranolol (ORF 12592) in dogs. Arch Int Pharmacodyn Ther. 1977 Jul;228(1):118-25. PubMed PMID: 921395.
