WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584936
Description: Orf 17578 is a histamine H2-receptor antagonist.
MedKoo Cat#: 584936
Name: Orf 17578
Chemical Formula: C15H22N4O3S
Exact Mass: 338.1413
Molecular Weight: 338.426
Elemental Analysis: C, 53.24; H, 6.55; N, 16.56; O, 14.18; S, 9.47
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Orf 17578; Orf-17578; Orf17578
IUPAC/Chemical Name: 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-2-nitro-N'-2-propynyl-
InChi Key: SMOHSULBMKXDEN-RVDMUPIBSA-N
InChi Code: InChI=1S/C15H22N4O3S/c1-4-7-16-15(11-19(20)21)17-8-9-23-12-14-6-5-13(22-14)10-18(2)3/h1,5-6,11,16-17H,7-10,12H2,2-3H3/b15-11+
SMILES Code: C#CCN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 338.426 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Katz LB, Scott CK, Shriver DA. Pharmacology of ORF 17578, a new histamine H2-receptor antagonist: comparison with cimetidine and ranitidine. J Pharmacol Exp Ther. 1986 May;237(2):404-10. PubMed PMID: 2871172.
2: Kosh JW, Sowell JW, Chapman JM. A comparison of the cholinergic activity of selected H2-antagonists and sulfoxide metabolites. Pharm Res. 1989 Aug;6(8):709-13. PubMed PMID: 2573049.
3: Alkadhi KA, Bassey EI, Hogan YH. A comparative study of the actions of histamine H2 receptor antagonists on transmission in the isolated superior cervical ganglion of the rat. Neuropharmacology. 1990 Mar;29(3):285-90. PubMed PMID: 1970132.